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The aims of our research are the improvement of fertility and the efficiency of reproductive biotechnologies in humans and animals, the study of the physiological and molecular mechanisms which determine the phenotypes of the descendants (health, growth, fertility, etc.) and the search for predictive and non-invasive biomarkers of these phenotypes, some of which could complement genetic selection strategies in animals. The unit draws on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, which cover the microscopic scale to the entire animal. In vitro models are also developed as alternatives to animal testing (primary cell cultures, organoids, embryoids). All of our expertise and tools are supplemented by clinical studies carried out by hospital and veterinary practitioners.

To achieve these objectives, the unit is organized into 5 research teams:

• Embryo and Pluripotency : Epigenetic and Environment (EPEE)
• Gonad Differentiation and its Perturbations (DGP)
• Placenta, Environment and Programming of PhenotypeS (PEPPS)
• Mécanismes épigénétiques et construction - prédiction des phénotypes (MECP2)
• Reproduction and Animal Models (RHuMA)