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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal University of Paris-Saclay UVSQ Ecole Nationale Vétérinaire d'Alfort SAPS Institut Carnot France Futur Elevage Biologie de la Reproduction, Environnement, Epigénétique et Développement

Biology of Reproduction, Environment, Epigenetics and Development

Zone de texte éditable et éditée et rééditée

Placenta, Environment and Programming of PhenotypeS (PEPPS)

Team leader: Anne Couturier-Tarrade (anne.couturier-tarrade@inrae.fr )

The PEPPS team includes staff from INRAE research departments "Human Nutrition and Food Safety (AlimH)"and "Animal Physiology and Farming (PhASE)" and from the National Veterinary School of Alfort (ENVA). This team, composed of 10 permanent staff members, has expertise in placental and animal physiology, medical imaging, histology, morphometry, lipidology, endocrinology and cellular and molecular biology. In addition, our team develops original approaches in gestation microscopy and imaging.

Team composition: Pascale Chavatte-Palmer (DR2), Andrew Ponter (Prof ENVA), Bénédicte Grimard (Prof ENVA), Anne Couturier-Tarrade (CRCN), Delphine Rousseau-Ralliard (CRCN), María-José Flores Sanabria (CRCN),  Michèle Dahirel (AI), Audrey Prézelin (AI), Emilie Derisoud (PhD student) and internship students (masters, technology institutes...)

Our objectives

To understand and modulate adaptations of placental function in response to the environment, being at the origin of changes in the post-natal phenotype.

Our group studies the role of the placenta on the establishment of fetal, post-natal and intergenerational phenotypes in relation to peri-conceptional and/or gestational disturbances of the maternal environment (nutrition, metabolic status, pollution, nanoparticles, food contaminants). Depending on the type of disturbance, the objective is to identify the window(s) of vulnerability and to understand the adaptive phenomena, in order to propose lifestyle or dietary recommendations for the mother, but also to determine whether placental biomarkers can be used to identify and predict the long-term phenotype of the offspring.

General topic

Intrauterine life imposes specific constraints on the embryo, and subsequently on the fetus, that affect the expression of its genetic potential. As a result, the uterine environment - reflecting various environmental factors, such as the mother's nutrition, embryonic manipulations or the biotic and abiotic stresses the mother has undergone - will affect the development, physiological capacities and health of the offspring up to adulthood. The observation of these effects in humans and then in animals has led to the emergence of the concept of the Developmental Origins of Health and Disease (DOHaD). This concept is based on the existence of a memory of the factors presents in early environment, whose molecular basis is the apposition of epigenetic marks that will regulate genome expression. The regulation of gene expression leads to structural and functional changes in tissues during development that, in adults, will be at the origin of individual variability of the phenotype and adaptation to new environmental stimuli. They are also capable of inducing predisposition or resistance to non-communicable diseases.

The placenta is a complex organ, associated with viviparity. It is formed after the attachment, or implantation, of the embryo to the uterine mucosa and derives from complex cellular and molecular interactions between uterine and embryonic tissues. In mammals, there are various forms of placentation but this organ has the same role in all species, essentially ensuring nutritional exchanges, endocrine and immunological functions between the mother and the fetus.

pepps-eng-001

Current or emerging scientific themes

  • Effects of maternal exposure, either by inhalation and/or oral route, to micro- and nanoparticles (diesel exhaust particles, metallic particles, food contaminants) on placental function and intrauterine and postnatal health of offspring up to the second generation (rabbit and mouse).
  • Impact of maternal conditions in the horse (nutrition, age, parity, metabolism, lactation concomitant with breeding) on the embryo quality, uterine environment, placental function and the metabolic and osteoarticular health of the foal. Strategies for mitigating these effects on the foal by modifying breeding conditions in the postnatal period are also evaluated.
  • Impact of parental obesity or hyperlipidic diet on placental function and health of offspring (human or animal models: rabbit or rat) and development of strategies to mitigate these effects by dietary supplementation (in rabbits) or bariatric surgery (in rats, in collaboration).
  • Development of cellular trophoblast models to evaluate the capture and passage of low-dose or mixed food contaminants on the placental barrier, their potential effects on placental function (hormonal production, nutrient exchange, cell fusion) or their genotoxic effects, as well as the mechanisms involved (human and rabbit trophoblast models).

Current and emerging work

pepps-eng-002

Expertise

Animal models:

  • Biomedical models: rabbit, mouse and sheep (rat in collaboration)
  • Livestock models: equine and ovine (pig, cattle, and goat in collaboration)

Disciplinary and technical skills:

  • Physiological explorations:
    • Placental function and fetal development  follow-up (by ultrasound and 3D reconstruction)
    • Glucose metabolism (IVGTT, OGTT, FSIVGTT, euglycemic hyperinsulinemic clamps)
    • Cardiovascular function (blood pressure, heart rate, implanted telemetry)
  • Animal handling: gavage, inhalation exposure, reproduction, /dissection of embryos/feto-placental units, collection of organs and biological fluids
  • Surgery: oocyte puncture, embryo transfer/collection, endoscopy/coelioscopy, interventions on the urogenital sphere, insertion of telemetric probes
  • In vivo imaging: ultrasound-Doppler 2D and 3D GE, Visualsonics micro-ultrasound, Cellvizio, osteodensitometry, iDXA GE  (MIMA2 infrastructure: https://www6.jouy.inrae.fr/mima2 )
  • Histology: classical histology (from paraffin or cryo sections), stereology, immuno-histo-chemistry
  • Ultrastructure: MET, MEB
  • Molecular function through Gene Expression: RT-qPCR, transcriptome analysis by RNAseq or microarray in collaboration)
  • Lipidology: fatty acid profiles by gas chromatography, using Varian 3900 GC-FID with SSL injection + Galaxie sofware and ThermoFisher 1310 GC-FID with SSL-PTV injections + Chromeleon sofware
  • Omics: Metabolomic, lipidomic and proteomic analyses in collaboration
  • Cell biology: cultures of rabbit trophoblastic stem cells and human cell lines
  • Biochemistry: endocrinology by Alphalisa and Elisa, clinical biochemistry

Experimental units and facilities used by the team:

The experimental programs are conducted in close interaction with the experimental units and facilities of INRAE SAAJ (rabbits and sheeps) and IERP (mice and rats), and with the experimental units of IFCE in Chamberet and at the Haras du Pin (for horses), that take care of the animals used by the team. Most of our programs use the resources and skills of the Ile-de-France - Jouy-en-Josas - Antony center :

  • MIMA2 in vivo and in vitro imaging platforms
  • Animal Surgery and Medical Imaging Platform (CIMA) of the MIMA2 platform
  • Transcriptomics and Histology Platforms of the @Bridge Platform

Funding

  • Effects of the maternal environment (micro- and nanoparticles, endocrine disruptors) on offspring
    • Programs in progress: ANSES ENORPREG, ANR EarlyNanoPathoLung, ANR FEDEXPO, Next-PlasTOX by INRAE AlimH funding, ANR PERMALI
    • Programs completed in 2017-2018: ANR EPAPP, ANSES BRAINAIRPOLL and ERC E-DOHAD
  • Impact of maternal and postnatal conditions in horses :
    • Programs in progress: IFCE EPAJ, IFCE FRAGMALIM and FRAGMALIM MARKER-OC
  • Strategies for mitigating and correcting the negative effects of the maternal environment during gestation
    • Program completed in 2017-2018: IFCE ARGIFOAL
  • Development of cellular trophoblast models
    • Internal financing INRAE AlimH (IntTropTox)

Partners

Regional

  • INRAE : GABI, PNCA, MICALIS
  • INSERM 1139 (Paris)
  • IMRB U955 (Créteil)
  • Small Animal Imaging Platform PIPA, Cochin Hospital, Paris
  • Trousseau Hospital (Pediatrics), Hospital Tenon (Biology of Reproduction), HEGP (Biochemistry) (Paris), Foch Hospital (transplantation)
  • PremUp Fundation

National

  • INRAE GenPhyse (Toulouse)
  • IFCE (Chamberet and Le Haras du Pin)
  • ANSES (Fougères)
  • IMRB-U955 (Créteil)
  • INSERM, INRA, INRS, Lorraine University and maternity (Nancy)
  • INSERM U292 (Grenoble)
  • UMR 7263 IMBE (Marseille)
  • Institute of Integrative Biology of the Cell (I2BC) (Gif sur Yvette)
  • Platform Génotoul-Metatoul (Toulouse)

International

  • European institutions: Veterinary School of Liège (Belgique), ETH, Zürich and EMPA (Suisse), RIVM, Bilthoven (Pays-Bas), HBRU (Luxembourg) and National Research Institute of the Working Environment (Danemark)
  • United States of America : Texas A&M

Affiliations

COST action Cellfit (CA 16119), (http://cost-cellfit.eu/), Pascale Chavatte-Palmer : MC member and Anne Couturier-Tarrade (MC member substitute)

International Embryo Technology Society (IETS, http://www.iets.org) - Pascale Chavatte-Palmer president

International Federation of Placenta Associations IFPA (http://www.ifpafederation.org)- Pascale Chavatte-Palmer is in the steering committee

European Placenta Group (europeanplacenta.com ) - Pascale Chavatte-Palmer is chairwoman

French society of DOHaD, SF-DOHaD (http://www.sf-dohad.fr) – Pascale Chavatte-Palmer founding member, Anne Couturier-Tarrade member of the board

Société Française de Nutrition (http://sf-nutrition.org/) – Delphine Rousseau-Ralliard, member of the Board of Directors

Groupe Lipid and Nutrition - Delphine Rousseau-Ralliard, member

CELPHEDIA infrastructure network (http://www.celphedia.eu/) – Delphine Rousseau-Ralliard, member of the working group WP4.1 rodent Phenotyping

Académie Vétérinaire de France (https://academie-veterinaire-defrance.org) – Pascale Chavatte-Palmer, corresponding member

Publications 2014-2020

Kick-starting ovarian cyclicity by using dietary glucogenic precursors in post-partum dairy cows: a review.  Kaewlamun W, Grimard B, Duvaux-Ponter C, Ponter AA. Int J Vet Sci Med. 2020 Jul 9;8(1):39-48. doi: 10.1080/23144599.2020.1773188.

Differential Effects of Post-Weaning Diet and Maternal Obesity on Mouse Liver and Brain Metabolomes. Safi-Stibler S, Thévenot EA, Jouneau L, Jouin M, Seyer A, Jammes H, Rousseau-Ralliard D, Baly C, Gabory A. Nutrients. 2020 May 28;12(6):1572. doi: 10.3390/nu12061572.

Preserved efficiency of sickle cell disease placentas despite altered morphology and function.  Cordier AG, Bouvier AS, Vibert F, Martinovic J, Couturier-Tarrade A, Lai-Kuen R, Curis E, Fournier T, Benachi A, Peoc'H K, Gil S. Placenta. 2020 Oct;100:81-88. doi: 10.1016/j.placenta.2020.08.008. Epub 2020 Aug 19. PMID: 32871493

Maternal obesity influences placental nutrient transport, inflammatory status and morphology in human term placenta.  Nogues P, Dos Santos E, Couturier-Tarrade A, Berveiller P, Arnould L, Lamy E, Grassin-Delyle S, Vialard F, Dieudonne MN. J Clin Endocrinol Metab. 2020 Sep 16:dgaa660. doi: 10.1210/clinem/dgaa660. Online ahead of print. PMID: 32936881

Female ponderal index at birth and idiopathic infertility.  Dupont C, Hulot A, Jaffrezic F, Faure C, Czernichow S, di Clemente N, Racine C, Chavatte-Palmer P, Lévy R; Alifert group. J Dev Orig Health Dis. 2020 Apr;11(2):154-158. doi: 10.1017/S2040174419000394. Epub 2019 Jul 16. PMID: 31309911

Contribution of Reproduction Management and Technologies to Genetic Progress in Horse Breeding. Palmer E, Chavatte-Palmer P. J Equine Vet Sci. 2020 Jun;89:103016. doi:n10.1016/j.jevs.2020.103016. Epub 2020 Apr 28. PMID: 32563446

Oocyte maturation under lipotoxic conditions induces carryover transcriptomic and functional alterations during post-hatching development of good-quality blastocysts: novel insights from a bovine embryo-transfer model. Desmet KLJ, Marei WFA, Richard C, Sprangers K, Beemster GTS, Meysman P, Laukens K, Declerck K, Vanden Berghe W, Bols PEJ, Hue I, Leroy JLMR. Human Reproduction, pp. 1–15, 2020 doi:10.1093/humrep/dez248

No-Contact Microchip Measurements of Body Temperature and Behavioural Changes Prior to Foaling. Auclair-Ronzaud, Juliette, Tristan Jousset, Cédric Dubois, Laurence Wimel, Florence Jaffrézic, et Pascale Chavatte-Palmer. Theriogenology 2020, 157 (novembre): 399‑406. https://doi.org/10.1016/j.theriogenology.2020.08.004.

No-Contact Microchip Monitoring of Body Temperature in Yearling Horses. Auclair-Ronzaud J, Benoist S, Dubois C, Frejaville M, Jousset T, Jaffrézic F, Wimel L, Chavatte-Palmer P. J Equine Vet Sci. 2020 Mar;86:102892. doi: 10.1016/j.jevs.2019.102892. Epub 2019 Dec 14.

Bovine scavenger receptor class A (SR-A) exhibit specific patterns of regulation in the endometrium during the oestrous cycle and early pregnancy. Vitorino Carvalho A, Eozenou C, Richard C, Forde N, Healey GD, Giraud-Delville C, Mansouri-Attia N, Lonergan P, Sheldon IM, Sandra O. Reproduction, Fertility and Development, 2019, 31 (6) : 1078-1090. Doi: 10.1071/RD18411

Deciphering the Impact of Early-Life Exposures to Highly Variable Environmental Factors on Foetal and Child Health: Design of SEPAGES Couple-Child Cohort. Lyon-Caen S, Siroux V, Lepeule J, Lorimier P, Hainaut P, Mossuz P, Quentin J, Supernant K, Meary D, Chaperot L, Bayat S, Cassee F, Valentino S, Couturier-Tarrade A, Rousseau-Ralliard D, Chavatte-Palmer P, Philippat C, Pin I, Slama R, Study Group TS. Int J Environ Res Public Health. 2019 Oct 14;16(20). pii: E3888. doi: 10.3390/ijerph16203888.

Anxiolytic- and Antidepressant-Like Effects of Fish Oil-Enriched Diet in Brain-Derived Neurotrophic Factor Deficient Mice. Zemdegs J, Rainer Q, Grossmann CP, Rousseau-Ralliard D, Grynberg A, Ribeiro E, Guiard BP. Front Neurosci. 2018 Dec 21;12:974. doi: 10.3389/fnins.2018.00974. eCollection 2018

Nano-analytical characterization of endogenous minerals in healthy placental tissue: mineral distribution, composition and ultrastructure. Anthis AHC, Tsolaki E, Didierlaurent L, Staubli S, Zboray R, Neels A, Dietrich D, Manser P, Desbiolles LM, Leschka S, Wildermuth S, Lehner S, Chavatte-Palmer P, Jochum W, Wick P, Dommann A, Bürki-Turnherr T, Fischer T, Hornung R, Bertazzo S, Herrmann IK. Analyst. 2019 Nov 18;144(23):6850-6857. doi: 10.1039/c9an01312a.

Repeated gestational exposure to diesel engine exhaust affects the fetal olfactory system and alters olfactory-based behavior in rabbit offspring. Bernal-Meléndez, E., Lacroix, M-C., Bouillaud, P., Callebert, J., Olivier, B., Persuy, M-A., Durieux, D., Rousseau-Ralliard, D., Aioun, J., Cassee, F., Couturier-Tarrade, A., Valentino, S., Chavatte-Palmer, P., Schroeder, H., Baly, C., 2019. Particle and Fibre Toxicology, 16:5 https://doi.org/10.1186/s12989-018-0288-7

Female ponderal index at birth and idiopathic infertility. Dupont, C., Hulot, A., Jaffrezic, F., Faure, C., Czernichow, S., Di Clemente, N., Racine, C., Chavatte-Palmer, P., Lévy, R., AlifertGroup, 2019. J Dev Orig Health Dis, in press, https://doi.org/10.1017/S2040174419000394

Metabolic syndrome and smoking are independent risk factors of male idiopathic infertility. Dupont, C., Faure, C., Daoud, F., Gautier, B., Czerichow, S., Levy, R., and the ALIFERT Collaborative Group dont Chavatte-Palmer, P., 2019. Basic Clin Androl, https://doi.org/10.1186/s12610-019-0090-x

Relationships between welfare and reproductive performance in French dairy herds. Grimard B, de Boyer des Roches A, Coignard M, Lehébel A, Chuiton A, Mounier L, Veissier I, Guatteo R, Bareille N. Vet J. 2019 Jun;248:1-7. doi: 10.1016/j.tvjl.2019.03.006. Epub 2019 Mar 28.

Sedentary behavior, physical inactivity and body composition in relation to idiopathic infertility among men and women. Foucault, A.M., Faure, C., Julia, C., Czernichow, S., Levy, R., Dupont, C., Aknin, I., Cedrin-Durnerin, I., Cens, S., Chavatte-Palmer, P., Hercberg, S., Pocate, K., Sermondade, N., Uthurriague, C., Wolf, J.P., 2019. Plos One, 14 (4).  http://dx.doi.org/10.1371/journal.pone.0210770

Impact of exposure to diesel exhaust during pregnancy on mammary gland development and milk composition in the rabbit. Hue-Beauvais, C., Aujean, E., Miranda, G., Ralliard-Rousseau, D., Valentino, S., Brun, N., Ladebese, S., Péchoux, C., Chavatte-Palmer, P., Charlier, M., 2019. Plos One, 14 (2): e0212132 https://www.ncbi.nlm.nih.gov/pubmed/30763367

Effect of Maternal Obesity and Preconceptional Weight Loss on Male and Female Offspring Metabolism and Olfactory Performance in Mice. Panchenko, P., Lacroix, M.-C., Jouin, M., Voisin, S., Badonnel, K., Lemaire, M., Meunier, N., Safi-Stibler, S., Persuy, M.-A., Jouneau, L., Durieux, D., Lecoutre, S., Jammes, H., Ralliard-Rousseau, D., Breton, C., Junien, C., Baly, C., Gabory, A., 2019. Nutrients, 11 (5), pii E948 https://www.ncbi.nlm.nih.gov/pubmed/31035463

Effects of dietary arginine supplementation in pregnant mares on maternal metabolism, placental structure and function and foal growth. Robles, M., Couturier-Tarrade, A., Derisoud, E., Geeverding, A., Dubois, C., Dahirel, M., Aioun, J., Prezelin, A., Calvez, J., Richard, C., Wimel, L., Chavatte-Palmer, P., 2019. Sci Rep, 9 (1), 6461  https://www.ncbi.nlm.nih.gov/pubmed/31015538

Effects of first-generation in utero exposure to diesel engine exhaust on second-generation placental function, fatty acid profiles and fœtal metabolism in rabbits: preliminary results. Rousseau-Ralliard, D., Valentino, S.A., Aubriere, M-C., Dahirel, M., Lallemand, M-S., Archilla, C., Jouneau, L., Fournier, N., Richard, C., Aioun, J., Vitorino Carbalho, A., Lecardonnel, J., Slama, R., Duranthon, V., Cassee, F.R., Chavatte-Palmer, P., Couturier-Tarrade, A., 2019. Sci Rep, 9 (1): 9710  https://www.ncbi.nlm.nih.gov/pubmed/31273257

Differentiation of derived rabbit trophoblast stem cells under fluid shear stress to mimic the trophoblastic barrier. Sanz, G., Daniel, N., Aubriere, M-C., Archilla, C, Jouneau, L., Jaszcyszyn, Y., Duranthon, V., Chavatte-Palmer, P., Jouneau, A., 2019. BBA Gen Subjects, 1863 (10): 1608-1618 https://www.ncbi.nlm.nih.gov/pubmed/31278960

A short periconceptional exposure to maternal type-1 diabetes is sufficient to disrupt the feto-placental phenotype in a rabbit model. Rousseau-Ralliard D., Couturier-Tarrade A., Thieme R., Brat R., Rolland A., Boileau P., Aubrière M.-C., Daniel N., Dahirel M., Derisoud E., Fournier N., Schindler M., Duranthon V., Fischer B., Santos A. N., and Chavatte-Palmer P. (2018). Molecular and Cellular Endocrinology. doi:10.1016/j.mce.2018.10.010

Critical steps for initiating an animal uterine transplantation model in sheep: Experience from a case series. Favre-Inhofer A, Carbonnel M, Revaux A, Sandra O, Mougenot V, Bosc R, Gelin V, Rafii A, Hersant B, Vialard F, Chavatte-Palmer P, Richard C, Ayoubi JM. Int J Surg. 2018 Dec;60:245-251. doi: 10.1016/j.ijsu.2018.11.017. Epub 2018 Nov 24.

Review: Epigenetics, developmental programming and nutrition in herbivores. Chavatte-Palmer P, Velazquez MA, Jammes H, Duranthon V. Animal. 2018 Aug 24:1-9. doi: 10.1017/S1751731118001337.

Impact of a gestational exposure to diesel exhaust on offspring gonadal development: experimental study in the rabbit. Bourdon M, Torres-Rovira L, Monniaux D, Faure C, Levy R, Tarrade A, Rousseau-Ralliard D, Chavatte-Palmer P, Jolivet G. J Dev Orig Health Dis. 2018 Jun 18:1-11. doi: 10.1017/S2040174418000351.

Placental function and structure at term is altered in broodmares fed with cereals from mid-gestation. Robles M, Peugnet P, Dubois C, Piumi F, Jouneau L, Bouchez O, Aubrière MC, Dahirel M, Aioun J, Wimel L, Couturier-Tarrade A, Chavatte-Palmer P. Placenta. 2018 Apr;64:44-52. doi: 10.1016/j.placenta.2018.02.003.

Long term effects of ART: What do animals tell us? Duranthon V, Chavatte-Palmer P. Mol Reprod Dev. 2018 Apr;85(4):348-368. doi: 10.1002/mrd.22970.

Review shows that maternal obesity induces serious adverse neonatal effects and is associated with childhood obesity in their offspring. Mitanchez D, Chavatte-Palmer P. Acta Paediatr. 2018 Jul;107(7):1156-1165. doi: 10.1111/apa.14269.

Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age. Robles M, Nouveau E, Gautier C, Mendoza L, Dubois C, Dahirel M, Lagofun B, Aubrière MC, Lejeune JP, Caudron I, Guenon I, Viguié C, Wimel L, Bouraima-Lelong H, Serteyn D, Couturier-Tarrade A, Chavatte-Palmer P. PLoS One. 2018 Jan 26;13(1):e0190309. doi: 10.1371/journal.pone.

Maternal parity affects placental development, growth and metabolism of foals until 1 year and a half. Robles M, Dubois C, Gautier C, Dahirel M, Guenon I, Bouraima-Lelong H, Viguié C, Wimel L, Couturier-Tarrade A, Chavatte-Palmer P. Theriogenology. 2018 Mar 1;108:321-330. doi: 10.1016/j.theriogenology.2017.12.019.

Placental structure and function in different breeds in horses. Robles M, Peugnet PM, Valentino SA, Dubois C, Dahirel M, Aubrière MC, Reigner F, Serteyn D, Wimel L, Tarrade A, Chavatte-Palmer P. Theriogenology. 2018 Mar 1;108:136-145. doi: 10.1016/j.theriogenology.2017.11.007.

Placental alterations in structure and function in intra-uterine growth-retarded horses. Robles M, Peugnet PM, Valentino SA, Dubois C, Dahirel M, Aubrière MC, Reigner F, Serteyn D, Wimel L, Couturier-Tarrade A, Chavatte-Palmer P. Equine Vet J. 2018 May;50(3):405-414. doi: 10.1111/evj.12761.

Contribution of Large Animals to Translational Research on Prenatal Programming of Obesity and Associated Diseases. Gonzalez-Bulnes A, Chavatte-Palmer P. Curr Pharm Biotechnol. 2017;18(7):541-551. doi: 10.2174/1389201018666170811150920.

Effect of maternal obesity on birthweight and neonatal fat mass: A prospective clinical trial. Mitanchez D, Jacqueminet S, Nizard J, Tanguy ML, Ciangura C, Lacorte JM, De Carne C, Foix L'Hélias L, Chavatte-Palmer P, Charles MA, Dommergues M. PLoS One. 2017 Jul 27;12(7):e0181307. doi: 10.1371/journal.pone.0181307.

Impact of equine assisted reproductive technologies (standard embryo transfer or intracytoplasmic sperm injection (ICSI) with in vitro culture and embryo transfer) on placenta and foal morphometry and placental gene expression. Valenzuela OA, Couturier-Tarrade A, Choi YH, Aubrière MC, Ritthaler J, Chavatte-Palmer P, Hinrichs K. Reprod Fertil Dev. 2018 Jan;30(2):371-379. doi: 10.1071/RD16536.

Maternal Nutrition during Pregnancy Affects Testicular and Bone Development, Glucose Metabolism and Response to Overnutrition in Weaned Horses Up to Two Years. Robles M, Gautier C, Mendoza L, Peugnet P, Dubois C, Dahirel M, Lejeune JP, Caudron I, Guenon I, Camous S, Tarrade A, Wimel L, Serteyn D, Bouraima-Lelong H, Chavatte-Palmer P.PLoS One. 2017 Jan 12;12(1):e0169295. doi: 10.1371/journal.pone.0169295.

Altered DNA methylation associated with an abnormal liver phenotype in a cattle model with a high incidence of perinatal pathologies. Kiefer H, Jouneau L, Campion É, Rousseau-Ralliard D, Larcher T, Martin-Magniette ML, Balzergue S, Ledevin M, Prézelin A, Chavatte-Palmer P, Heyman Y, Richard C, Le Bourhis D, Renard JP, Jammes H. Sci Rep. 2016 Dec 13;6:38869. doi: 10.1038/srep38869.

Correction: Effects of Moderate Amounts of Barley in Late Pregnancy on Growth, Glucose Metabolism and Osteoarticular Status of Pre-Weaning Horses. Peugnet P, Robles M, Mendoza L, Wimel L, Dubois C, Dahirel M, Guillaume D, Camous S, Berthelot V, Toquet MP, Richard E, Sandersen C, Chaffaux S, Lejeune JP, Tarrade A, Serteyn D, Chavatte-Palmer P. PLoS One. 2016 Dec 2;11(12):e0167604. doi: 10.1371/journal.pone.0167604.

Non-invasive evaluation of placental blood flow: lessons from animal models. Mourier E, Tarrade A, Duan J, Richard C, Bertholdt C, Beaumont M, Morel O, Chavatte-Palmer P. Reproduction. 2017 Mar;153(3):R85-R96. doi: 10.1530/REP-16-0428.

Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits. Valentino SA, Tarrade A, Aioun J, Mourier E, Richard C, Dahirel,M, Rousseau-Ralliard D, Fournier N, Aubrière MC, Lallemand MS, Camous S, Guinot M, Charlier M, Aujean E, Al Adhami H, Fokkens PH, Agier L, Boere JA, Cassee FR, Slama R, Chavatte-Palmer P. Part Fibre Toxicol. 2016 Jul 26;13(1):39. doi: 10.1186/s12989-016-0151-7.

Diet before and during Pregnancy and Offspring Health: The Importance of Animal Models and What Can Be Learned from Them. Chavatte-Palmer P, Tarrade A, Rousseau-Ralliard D. Int J Environ Res Public Health. 2016 Jun 14;13(6). pii: E586. doi: 10.3390/ijerph13060586.

Placentation in different mammalian species. Chavatte-Palmer P, Tarrade A. Ann Endocrinol (Paris). 2016 Jun;77(2):67-74. doi: 10.1016/j.ando.2016.04.006.

Management of the pregnant mare and long-term consequences on the offspring. Peugnet P, Robles M, Wimel L, Tarrade A, Chavatte-Palmer P. Theriogenology. 2016 Jul 1;86(1):99-109. doi: 10.1016/j.theriogenology.2016.01.028.

Eicosapentaenoic acid membrane incorporation impairs ABCA1-dependent cholesterol efflux via a protein kinase A signaling pathway in primary human macrophages. Fournier N, Tardivel S, Benoist JF, Vedie B, Rousseau-Ralliard D, Nowak M, Allaoui F, Paul JL. Biochim Biophys Acta. 2016 Apr;1861(4):331-41. doi: 10.1016/j.bbalip.2016.01.002. Epub 2016 Jan 8

[Impact of maternal obesity and diabetes on placental function]. Gabory A, Chavatte-Palmer P, Vambergue A, Tarrade A. Med Sci (Paris). 2016 Jan;32(1):66-73. doi: 10.1051/medsci/20163201011.

[DOHaD and pre- or peri-conceptional programming]. Chavatte-Palmer P, Vialard F, Tarrade A, Dupont C, Duranthon V, Lévy R. Med Sci (Paris). 2016 Jan;32(1):57-65. doi: 10.1051/medsci/20163201010.

Discriminative imaging of maternal and fetal blood flow within the placenta using ultrafast ultrasound. Osmanski BF, Lecarpentier E, Montaldo G, Tsatsaris V, Chavatte-Palmer P, Tanter M. Sci Rep. 2015 Sep 16;5:13394. doi: 10.1038/srep13394.

The Wound Healing and Antibacterial Activity of Five Ethnomedical Calophyllum inophyllum Oils: An Alternative Therapeutic Strategy to Treat Infected Wounds. Léguillier T, Lecsö-Bornet M, Lémus C, Rousseau-Ralliard D, Lebouvier N, Hnawia E, Nour M, Aalbersberg W, Ghazi K, Raharivelomanana P, Rat P. PLoS One. 2015 Sep 25;10(9):e0138602. doi: 10.1371/journal.pone.0138602. eCollection 2015

In Vivo Evaluation of Cervical Stiffness Evolution during Induced Ripening Using Shear Wave Elastography, Histology and 2 Photon Excitation Microscopy: Insight from an Animal Model. Peralta L, Mourier E, Richard C, Charpigny G, Larcher T, Aït-Belkacem D, Balla NK, Brasselet S, Tanter M, Muller M, Chavatte-Palmer P. PLoS One. 2015 Aug 28;10(8):e0133377. doi: 10.1371/journal.pone.0133377.

A perspective on the developmental toxicity of inhaled nanoparticles. Hougaard KS, Campagnolo L, Chavatte-Palmer P, Tarrade A, Rousseau-Ralliard D, Valentino S, Park MV, de Jong WH, Wolterink G, Piersma AH, Ross BL, Hutchison GR, Hansen JS, Vogel U, Jackson P, Slama R, Pietroiusti A, Cassee FR. Reprod Toxicol. 2015 Aug 15;56:118-40. doi: 10.1016/j.reprotox.2015.05.015.

Milk from dams fed an obesogenic diet combined with a high-fat/high-sugar diet induces long-term abnormal mammary gland development in the rabbit. Hue-Beauvais C, Koch E, Chavatte-Palmer P, Galio L, Chat S, Letheule M, Rousseau-Ralliard D, Jaffrezic F, Laloë D, Aujean E, Révillion F, Lhotellier V, Gertler A, Devinoy E, Charlier M. J Anim Sci. 2015 Apr;93(4):1641-55. doi: 10.2527/jas.2014-8139.

Effects of moderate amounts of barley in late pregnancy on growth, glucose metabolism and osteoarticular status of pre-weaning horses. Peugnet P, Robles M, Mendoza L, Wimel L, Dubois C, Dahirel M, Guillaume D, Camous S, Berthelot V, Toquet MP, Richard E, Sandersen C, Chaffaux S, Lejeune JP, Tarrade A, Serteyn D, Chavatte-Palmer P. PLoS One. 2015 Apr 13;10(4):e0122596. doi: 10.1371/journal.pone.0122596. eCollection 2015. Erratum in: PLoS One. 2016 Dec 2;11(12):e0167604.

Transcervical collection of bovine embryos up to Day 21: an 8-year overview. Richard C, Hue I, Gelin V, Neveux A, Campion E, Degrelle SA, Heyman Y, Chavatte-Palmer P. Theriogenology. 2015 Apr 15;83(7):1101-9. doi: 10.1016/j.theriogenology.2014.12.005. Epub 2014 Dec 15.

Breeding animals for quality products: not only genetics. Chavatte-Palmer P, Tarrade A, Kiefer H, Duranthon V, Jammes H. Reprod Fertil Dev. 2016;28(1-2):94-111. doi: 10.1071/RD15353.

Placental contribution to nutritional programming of health and diseases: epigenetics and sexual dimorphism. Tarrade A, Panchenko P, Junien C, Gabory A. J Exp Biol. 2015 Jan 1;218(Pt 1):50-8. doi: 10.1242/jeb.110320. Review.

Are semen parameters related to birth weight? Faure C, Dupont C, Chavatte-Palmer P, Gautier B, Levy R; ALIFERT Collaborative Group. Fertil Steril. 2015 Jan;103(1):6-10. doi: 10.1016/j.fertnstert.2014.11.027.

[Placental 3D Doppler angiography: current and upcoming applications]. Duan J, Perdriolle-Galet E, Chabot-Lecoanet AC, Callec R, Beaumont M, Chavatte-Palmer P, Tsatsaris V, Morel O. J Gynecol Obstet Biol Reprod (Paris). 2015 Feb;44(2):107-18. doi: 10.1016/j.jgyn.2014.09.007. Epub 2014 Oct 11. Review. French.

UCP1 is present in porcine adipose tissue and is responsive to postnatal leptin. Mostyn A, Attig L, Larcher T, Dou S, Chavatte-Palmer P, Boukthir M, Gertler A, Djiane J, E Symonds M, Abdennebi-Najar L. J Endocrinol. 2014 Oct;223(1):M31-8. doi: 10.1530/JOE-14-0155. Epub 2014 Aug 13.

Enhanced or reduced fetal growth induced by embryo transfer into smaller or larger breeds alters post-natal growth and metabolism in pre-weaning horses. Peugnet P, Wimel L, Duchamp G, Sandersen C, Camous S, Guillaume D, Dahirel M, Dubois C, Jouneau L, Reigner F, Berthelot V, Chaffaux S, Tarrade A, Serteyn D, Chavatte-Palmer P. PLoS One. 2014 Jul 9;9(7):e102044. doi: 10.1371/journal.pone.0102044. eCollection 2014.

Impact of maternal hyperlipidic hypercholesterolaemic diet on male reproductive organs and testosterone concentration in rabbits. Dupont C, Ralliard-Rousseau D, Tarrade A, Faure C, Dahirel M, Sion B, Brugnon F, Levy R, Chavatte-Palmer P. J Dev Orig Health Dis. 2014 Jun;5(3):183-8. doi: 10.1017/S2040174414000087.

Maternal high-fat diet induces follicular atresia but does not affect fertility in adult rabbit offspring. Léveillé P, Tarrade A, Dupont C, Larcher T, Dahirel M, Poumerol E, Cordier AG, Picone O, Mandon-Pepin B, Jolivet G, Lévy R, Chavatte-Palmer P. J Dev Orig Health Dis. 2014 Apr;5(2):88-97. doi: 10.1017/S2040174414000014.

Analysis of placental vascularization in a pharmacological rabbit model of IUGR induced by L-NAME, a nitric oxide synthase inhibitor. Tarrade A, Lecarpentier E, Gil S, Morel O, Zahr N, Dahirel M, Tsatsaris V, Chavatte-Palmer P. Placenta. 2014 Apr;35(4):254-9. doi: 10.1016/j.placenta.2014.01.013. Epub 2014 Feb 6.

Are superoxide dismutase 2 and nitric oxide synthase polymorphisms associated with idiopathic infertility? Faure C, Leveille P, Dupont C, Julia C, Chavatte-Palmer P, Alifert Group, Sutton A, Levy R. Antioxid Redox Signal. 2014 Aug 1;21(4):565-9. doi: 10.1089/ars.2014.5831. Epub 2014 Feb 25.

Contrasting effects of arachidonic acid and docosahexaenoic acid membrane incorporation into cardiomyocytes on free cholesterol turnover. Doublet A, Robert V, Vedie B, Rousseau-Ralliard D, Reboulleau A, Grynberg A, Paul JL, Fournier N. Biochim Biophys Acta. 2014 Oct;1842(10):1413-21. doi: 10.1016/j.bbalip.2014.07.003. Epub 2014 Jul 11