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Équipe Génétique et Génomique Bovine (G2B)

 CV :

• Ingénieure INRAE
  • Depuis 2012: Génétique Bovine (équipe G2B)
  • 2000-2012: Génétique porcine
  • 1998-2000: Génétique des poissons
• 2019: Thèse de doctorat de l'Université Paris-Saclay, préparée à AgroParisTech, spécialité Génétique Animale
• 1998: D.E.A. de Biologie des Populations, Génétique et Ecoéthologie, option Génétique Quantitative, INA-PG, Université de Tours, Université de Rennes
• 1997: Maîtrise de Biologie des Populations et des Ecosystèmes, Université de Montpellier II

Domaines de recherche : 

Analyse de la variabilité génétique des caractères; Détection, cartographie fine et caractérisation de QTL; Déterminisme de la composition et des propriétés du lait; Déterminisme génétique de la résistance à la paratuberculose; Génétique quantitative ; Sélection génomique; Evaluation génétique des reproducteurs

Autres activités :

• Correspondante qualité du périmètre certifié ISO9001 "Evaluation génétique des reproducteurs bovins" (2013-2018)
• Enseignement dans le cadre du Master Priam

Publications :

Sanchez M.P., Escouflaire C., Baur A., Bottin F., Hoze C., Boussaha M., Capitan A., Fritz S., Capitan A., Boichard D. 2023. X-linked genes influence various complex traits in dairy cattle. BMC Genomics, 24:338.

Sahana G, Cai Z., Sanchez M.P., Bouwman A., Boichard D. 2023. Invited review: Good practices in genome-wide association studies to identify candidate sequence variants in dairy cattle. J Dairy Sci, 106.

Sanchez M.P., Tribout T., Fritz S., Guatteo R., Fourichon C., Schibler L., Delafosse A., Boichard D. 2022. New insights into genetic resistance to paratuberculosis in Holstein cattle via a single-step genomic evaluation. Genet Sel Evol, 54: 67.

Sanchez M.P., Tribout T., Fritz S., Wolf V., Laithier C., Brochard M., Boichard D. 2022. Opportunities for genomic selection of cheese-making traits in Montbéliarde cows. J Dairy Sci, 105, 5206-5220.

Costes V., Chaulot-Talmon A., Sellem E., Perrier J.P., Aubert-Frambourg A., Jouneau L., Pontlevoy C., Hozé C., Fritz S., Boussaha M., Le Danvic C., Sanchez M.P., Boichard D., Schibler L., Jammes H., Jaffrézic F., Kiefer H. 2022. Predicting male fertility from the sperm methylome: application to 120 bulls with hundreds of artificial insemination records. Clinical Epigenetics 14, 54

Xiang R., Fang L., Sanchez M.-P., Cheng H. & Zhang Z. 2022. Editorial: multi-layered genome-wide association and prediction in animals. Frontiers in genetics, 13:877748.

Sanchez M.P., Rocha D., Charles M., Boussaha M., Hozé C., Brochard M., Delacroix-Buchet A., Grosperrin P., Boichard D. 2021. Sequence-based GWAS and post-GWAS analyses reveal a key role of SLC37A1 and ANKH genes and gene regulatory regions on bovine milk minerals. Scientific Reports, 11, 7537.

Bourdon C, Boussaha M, Bardou P, Sanchez MP, Le Guillou S, Tribout T, Larroque H, Boichard D, Rupp R, Le Provost F, Tosser-Klopp G. 2021. In silico whole genome SNP datasets analyses identify variations in microRNAs with a potential impact on dairy traits in bovine, caprine and ovine species. Scientific Reports 11, 19580.

Tribout T., Croiseau P., Lefebvre R.,  Barbat A., Boussaha M., Fritz S., Boichard D., Hoze C., Sanchez M.P. 2020. Confirmed candidate causative variants for milk production, udder health and udder morphology in dairy cattle. Genet Sel Evol, 52, 55.

Sanchez M.P., Fritz S., Patry C., Delacroix-Buchet A., Boichard D. 2020. Milk protein variant and haplotype frequencies estimated from genotypes of more than one million bulls and cows of twelve French cattle breeds. J Dairy Sci, 103, 9124-9141.

Van Den Berg I., Xiang R., Jenko J., Pausch H., Boussaha M., Tribout T., Gjuvsland A.B., Boichard D., Nordbø Ø., Sanchez M-P., Goddard M.E. 2020. Large scale multi breed meta-analysis for fat and protein percentage using imputed sequence variant genotypes in 94,321 cattle from eight dairy breeds. Genet Sel Evol, 52, 37.

Sanchez M.-P., Guatteo R., Davergne A., Grohs C., Taussat S., Fritz S., Boussaha M., Blanquefort P., Delafosse A., Joly A., Schibler L., Fourichon C., Boichard D. 2020. Identification of the ABCC4, IER3, and CBFA2T2 candidate genes for resistance to paratuberculosis from sequence-based GWAS in Holstein and Normande dairy cattle. Genet Sel Evol 52:14.

Laithier C., Wolf V., Brochard M., Sanchez M.-P., Gaudillière N., Minéry S., Fritz S., Gavoye S., Gaüzère Y., Rolet-Répécaud O., Notz E., Bouton Y., Boichard D., Grosperrin P. and Delacroix-Buchet A. 2020. FROM’MIR : Développer des outils de prédiction et de conseil pour maîtriser la fromageabilité des laits destinés à la fabrication des fromages traditionnels franc-comtois. Innovations Agronomiques 79, 227-244.

Sanchez M.P., Wolf V., Laithier C., El Jabri M., Beuvier E., Rolet-Repecaud O., Gaudilliere N., Minery S., Ramayo-Caldas Y., Tribout T., Michenet A., Boussaha M., Taussat S., Fritz S., Delacroix-Buchet A., Grosperrin P., Brochard M., Boichard D. 2019. Analyse génétique de la fromageabilité du lait de vache prédite par spectrométrie moyen infrarouge en race Montbéliarde. INRAE Prod Anim, 32, 379-398.

Sanchez M.P., Ramayo-Caldas Y., Wolf V., Laithier C., El Jabri M., Michenet A., Boussaha M., Taussat S., Fritz S., Delacroix-Buchet A., Brochard M., Boichard D. 2019. Sequence-based GWAS, network and pathway analyses reveal genes co-associated with milk cheese making properties and milk composition in Montbéliarde cows. Genet Sel Evol, 51, 34.

El Jabri M., Sanchez M.P., Trossat P., Laithier C., Wolf V., Grosperrin P., Beuvier E., Rolet-Répécaud O., Gavoye S., Gauzere Y., Belysheva O., Notz E., Boichard D., Delacroix-Buchet A. 2019. Comparison of Bayesian and PLS regression methods for mid-infrared prediction of cheese-making properties in Montbéliarde cows. J Dairy Sci., 102:6943–6958.

Sanchez M.P., El Jabri M., Minery S., Wolf V., Beuvier E., Laithier C., Delacroix-Buchet A., Brochard M., Boichard D. 2018. Genetic parameters for cheese-making properties and milk composition predicted from mid-infrared spectra in a large dataset of Montbéliarde cows. J Dairy Sci, 101, 10048–10061.

Sanchez M.P., Wolf V., El Jabri M., Beuvier E., Rolet-Repecaud O., Gauzere Y., Minery S., Brochard M., Michenet A., Taussat S., Barbat-Leterrier A., Delacroix-Buchet A., Laithier C., Fritz S., Boichard D. 2018. Short-communication: Confirmation of candidate causative variants on milk composition and cheese-making properties in Montbéliarde cows. J Dairy Sci, 101, 10076–10081.

Bouwman A.C., Daetwyler H.D., Chamberlain A.J., Hurtado Ponce C., Sargolzaei M., Schenkel F.S., Sahana G., Govignon-Gion A., Boitard S., Dolezal M., Pausch H., Brøndum R.F., Bowman P.J., Thomsen B., Guldbrandtsen B., Lund M.S., Servin B., Garrick D.J., Reecy J., Vilkki J., Bagnato A., Wang M., Hoff J.L., Schnabel R.D., Taylor J.F., Vinkhuyzen A.A.E., Panitz F., Bendixen C., Holm L.E., Gredler B., Hozé C., Boussaha M., Sanchez M.P., Rocha D., Capitan A., Tribout T., Barbat A., Croiseau P., Drögemüller C., Jagannathan V., Vander Jagt C., Crowley J.J., Intergenomics Consortium, Bieber A., Purfield D.C., Berry D.P., Emmerling R., Götz K.U., Van Tassell C.P, Fries R., Stothard P., Veerkamp R.F., Boichard D., Goddard M.E., Hayes B.J.  2018. Meta-analysis of genome wide association studies for the stature of cattle reveals common genes that regulate size in mammals. Nat. Genet., 50, 362-367.

Teissier M., Sanchez M-P., Boussaha M., Barbat-Leterrier A., Hozé C., Robert-Granié C., Croiseau P. 2018. Use of meta-analyses and joint analyses to select variants in whole genome sequences for genomic evaluation : an application in milk production of French dairy cattle breeds. J Dairy Sci. 101: 3126-3139.

Sanchez M.P., Govignon-Gion A., Croiseau P., Fritz S., Hoze C., Miranda G., Martin P., Barbat-Leterrier A., Brochard M., Boussaha M., Boichard D. 2017. Within-breed and multi-breed GWAS on imputed whole genome sequence variants reveal candidate mutations affecting milk protein composition in dairy cattle. Genet Sel Evol, 49:68.

Jonas D., Ducrocq V., Fritz S., Baur A., Sanchez M.P., Croiseau P. 2017. Genomic evaluation of regional dairy cattle breeds in single-breed and multibreed contexts. J. Anim. Breed. Genet., 134:3-13.

Sanchez M.P., Govignon-Gion A., Ferrand M., Gele M., Pourchet D., Miranda G., Martin P., Brochard M., Boichard D. 2017. Short-communication: Genetic parameters for milk protein composition in the French Montbéliarde, Normande and Holstein dairy cattle breeds. J Dairy Sci, 100, 6371-6375.

Sanchez M.P. , Govignon-Gion A., Ferrand M., Gele M., Pourchet D., Amigues Y., Fritz S., Boussaha M., Capitan A., Rocha D., Miranda G., Martin P., Brochard M., Boichard D. 2016. Whole genome scan to detect SNP associated to milk protein composition in three French dairy cattle breeds. J Dairy Sci, 99, 8203–8215.

Boichard D., Govignon-Gion A., Larroque H., Maroteau C., Palhiere I., Tosser-Klopp G., Rupp R., Sanchez M.P., Brochard M. 2014. Déterminisme génétique de la composition en acides gras et protéines du lait des ruminants. INRA Prod Anim, 27, 283-298.

Legarra A., Croiseau P., Sanchez M.P., Teyssèdre S., Sallé G., Allais S., Fritz S., Moreno C., Ricard A., Elsen J.M. 2014. A comparison of methods for whole-genome QTL fine mapping using dense markers in four livestock species. Genet. Sel. Evol., 47:6.

San Cristobal M., Sanchez M.P., Mercat M.J., Rohart F., Liaubet L., Tribout T., Canlet C., Muller N., Molina J., Iannucelli N., Laurent B., Villa-Vialaneix N., Paris A., Milan D. 2014. Le métabolome, un moyen pour trouver de nouveaux biomarqueurs ? Viandes et produits carnés 2014-30-2-1.

Sanchez M.P., Tribout T., Iannuccelli N., Bouffaud M., Servin B., Dehais P., Muller D., Tenghe A., Mercat M.J., Bidanel J.P., Rogel-Gaillard C., Milan D., Gilbert H. 2014. Genome wide association study in a Large White commercial population for production traits: evidence of a haplotype affecting meat quality traits. Genet. Sel. Evol., 46:12.

Hernandez S.C., Hogg C.O., Billon Y., Sanchez M.P., Bidanel J.P., Haley C.S., Archibald A.L., Ashworth C.J. 2013. Secreted phosphoprotein 1 expression in endometrium and placental tissues of Hyperprolific Large white and Meishan gilts. Biol. Reprod. 88, 120.

Gondret F., Riquet J., Tacher S., Demars J., Sanchez M.P., Billon Y., Robic A., Bidanel J.P., Milan D. 2011. Towards candidate genes affecting body fatness at SSC7 QTL by expression analyses. J. Anim. Breed. Genet. 129, 316-324.

Tortereau F., Sanchez M.P., Feve K., Gilbert H., Iannuccelli N., Billon Y., Milan D., Bidanel J.P., Riquet J. 2011. Progeny-testing of full-sibs IBD on a SSC2 QTL region highlights epistatic interactions for fatness traits in pigs. BMC Genet. 12, 92.

Riquet J., Gilbert H., Servin B., Sanchez M.P., Iannuccelli N., Billon Y., Milan D., Bidanel J.P. 2011. A locally congenic backcross design in pig : a new regional fine QTL mapping approach miming congenic strains used in mouse. BMC Genet. 12, 6.

Sanchez M.P., Iannuccelli N., Basso B., Foury A., Billon Y., Gandemer G., Gilbert H., Mormède P., Bidanel J.P., Larzul C., Riquet J., Milan D., Le Roy P. 2011. Microsatellite mapping of QTL affecting meat quality, stress hormones and production traits in Duroc x Large White F2 pigs. Animal 5, 167-174.

Demars J., Riquet J., Sanchez M.P., Billon Y., Hocquette J.F., Lebret B., Iannuccelli N., Bidanel J.P., Milan D., Gondret F. 2007. Metabolic and histochemical characteristics of fat and muscle tissues in homozygous or heterozygous pigs for the body composition QTL located on chromosome 7. Physiol Genom. 30: 232-241.

Sanchez M.P., Iannuccelli N., Basso B., Bidanel J.P., Billon Y., Gandemer G., Gilbert H., Larzul C., Legault C., Riquet J., Milan D., Le Roy P. 2007. Identification of QTL with effects on intramuscular fat content and fatty acid composition in a Duroc x Large White cross. BMC Genet., 8:55.

Damon M., Louveau I., Lefaucheur L., Lebret B., Vincent A., Le Roy P., Sanchez M. P., Herpin P., Gondret F. 2006. Number of intramuscular adipocytes and fatty acid binding protein-4 content are significant indicators of intramuscular fat level in crossbred Large White X Duroc pigs. J. Anim. Sci., 84, 1083-1092.

Sanchez M.P., Riquet J., Iannuccelli N., Gogué J., Demeure O., Billon Y., Caritez J.C., Burgaud G., Fève K., Bonnet M., Péry C., Lagant H., Le Roy P., Bidanel J.P., Milan D. 2006. Effects of QTL on chromosomes 1, 2, 4 and 7 for growth, carcass and meat quality traits in backcross Meishan x Large White pigs. J. Anim. Sci., 84, 526-537.

Demeure O., Sanchez M.P., Riquet J., Iannuccelli N., Demars J., Feve K., Gogue J., Billon Y., Caritez J.C., Milan D., Bidanel J.P. 2005. Exclusion of the SLA as candidate region and reduction of the position interval for the porcine chromosome 7 QTL affecting growth and fatness. J. Anim. Sci., 83, 1979-1987.

Foury A., Devillers N., Sanchez M.P., Griffon H., Le Roy P., Mormède P. 2005. Stress hormones, carcass composition and meat quality in Large White x Duroc pigs. Meat Sci., 69, 703-707.

Mambrini M., Sanchez M.P., Chevassus B., Labbé L., Quillet E., Boujard T 2004. Selection for growth increases feed intake and affects feeding behavior of brown trout. Livest. Prod. Sci., 88, 85-98.

Mambrini M., Médale F., Sanchez M.P., Recalde B., Chevassus B., Labbé L., Quillet E., Boujard T 2004. Selection for growth in brown trout increases feed intake capacity without affecting maintenance and growth requirements. J. Anim. Sci., 82, 2865-2875.

Sanchez M.P., Bidanel J.P., Zhang S., Naveau J., Burlot T., Le Roy P. 2003. Likelihood and bayesian approaches reveal major genes affecting body composition, carcass, meat quality and number of good teats in a Chinese European pig line. Genet. Sel. Evol., 35, 385-402.

Sanchez M.P., Chevassus B., Labbé L., Quillet E., Mambrini M. 2001. Selection for growth of brown trout (Salmo trutta) affects feed intake but not feed efficiency. Aquat. Living Resour., 14, 41-48.