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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal AgroParisTech Université Paris-Saclay

INRA GABI Unit

GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

A CIFRE PhD project is now available : applications now open in bovine genomics

@INRAE
This thesis project is aimed at statistically exploring the impact of transgenerational epigenetics in cattle and to investigate its genetic components. This doctoral project will be in close partnership with INRAE and the French Breeding Institute as part of the UMT-eBIS whose research is focused on bovine genomics and in particular genetic evaluation tools and trait architecture.

Context and objectives of the PhD:

Bovine breeding must now answer the requirements of a triple economic, environmental and social performance providing a sufficient salary to breeders and meet the challenges of food autonomy and the increasing demand for food world wide.Genetic and genomic selection is a key factor to the overall efficiency and sustainability of the bovine sector. Economic and environmental efficiency of farms depends on the genetic level of the animals and herd management (diet, health, reproduction ...). However, many studies in model species and in man have shown that the environment influences genome expression via epigenetic mechanisms that may not only modulate genome expression of an individual, but that may also effect the epigenome of progeny and modulate the expression of the genetic potential of the animal's descendants. The PhD project is aimed at answering the fundamental questions pertaining to the following: (the genetic control of the sperm epigenome)(meQTL of DNA methylation and eQTL from small non-coding RNA), (ii) the role of DNA methylation in the evolution of the bovine genome (appearance of neo-mutations and frequency of meiotic recombinations), (iii) the impact of sperm epigenomic and fetal programming on the performances of the descendants.

The resultats obtained should favor innovations for the partners of Eliance and breeders. The analysis of genetic control of the epigenome and its relationship with recombination frequency will improve selection of reproducers. The understanding of the impact of the epigenome on the performances of progeny, will we hope allow for the integration of new elements into performance prediction tools and the improvement of farm animal management. The PhD student will be implicated in thoughts on on-site applications issued from these studies and their diffusion to Eliance members.

Profile and aptitudes:

You are in possession of a Bac+ degree with a first experience in genetics.

You are well familiar with statstical software (R, SAS, ) and you are interested in biology, bioinformatics and high-throughput data analysis.

Knowledge of agonomy and animal phsiology are well apreciated.

You are autonomous, curious, rigorous and enjoy taking initiatives. You like working within a multidisciplinary team and have a good capacity to adapt.
You have a good level of written and spoken English.

Conditions for the position:

The position is located on the INRAE Jouy-en-Josas campus (78).

There will be frequent travelling in France (3 to 6 months) and abroad (international meetings: once per year).

Up to 3 days of home working is possible once the trial period is over.

Information and to apply:
Send your CV and cover letter to chris.hoze@eliance.fr
deadline: 15/06/2022.

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