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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal AgroParisTech Université Paris-Saclay

INRA GABI Unit

GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

We are receiving applications for a financed PhD.

INRAE
The PhD student will contribute to predicting and characterizing pluripotency states of the pig embryo by analyzing in silico multi-omics unicellular data.

Field and key words

Bioinformatics, data analysis, single cell, pig embryos, experimental validation.

PhD project context

The global changes currently underway (global warmining, availability of agricultural resources, society's perception of farming, sanitary importance of zoonoses) have imposed that we rethink our production systems. The pression of animal production on the ecosystem should be reduced, food security and health must increase and the consideration for animal welfare in farming must increase. To reach these overall objectives, integration of the digital dimension in health management in farming is essential and its coupling with innovative cell systems will allow high-throughput evaluation of phenotypes that are difficult to measure in animal husbandry or on live animals. By doing this, sufficient quantities of data adapted to the methodologies developed for "big data" can be acquired. This strategy also reduces the need for animal experimentation in agreement with the 3R (Replacement, Reduction and Refinement). Thus human pluripotent stem cell biobanks are now being widely used in biomedicine to model complex traits and diseases.

We propose, as part of this project, to use the digital dimension of multi-omics data at the unique cell and tissue scale to predict the molecules necessary and sufficient for maintaining pig pluripotency and to transfer this knowledge for its use in production and to use the porcine pluripotent stem cell lines for animal and human health applications.

This approach, which represents a break with traditional experimental approaches, will be a major step forwards for genetic, pharmaceutical or toxicological studies. It has attracted attention from the French Porcine Institut (IFIP-Institut du Porc) and other partner companies. Indeed, improving disease resistance of animals has been, for many years, a research priority that has had trouble making progress due to lack of high-throughput phenotyping methods. This project opens real perspectives and is completely in line with the concept and objectives of DIM One Health.

Contact & applications:

Hervé Acloque

Adress : INRAE – UMR1313 GABI – Equipe GeMS - bâtiment 320 – 78350 Jouy-en-Josas
Telephone : 01 34 65 28 10  Mail : herve.acloque@inrae.fr

Organism or establishment: Université Paris Saclay – AgroParisTech

Name of the hosting research unit

UMR1313 Génétique Animale et Biologie Intégrative (GABI)
Unit head: Claire Rogel-Gaillard
Telephone : 01 34 65 22 01 Mail : claire.rogel-gaillard@inrae.fr

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