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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal AgroParisTech Université Paris-Saclay


GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

Call for a thesis project

INRA-PASTEUR doctoral project
Prevent salmonella propagation in laying hen farms: the study of the effect of host genetic variations and the intestinal microbiota composition on intestinal carriage in mice and chickens.

An INRA – Région Ile-de-France (appel Dim1Health) 2018-2021 grant is planned.

Hosting Laboratoiries – Suppervisors – Contacts
Fanny Calenge (CR) – 01 34 65 29 14,
Genetics, Immunity, Health Team (GIS),
UMR Animal Genetics and Integrative Biology (GABI),
INRA, Domaine de Vilvert, Bât 320, 78352 Jouy-en-Josas cedex
Jean Jaubert (CR) – 01 44 38 95 17,
Mouse Genetics Laboratory (LGS),
Genomes and Genetics Department (GG),
Institut Pasteur, 25-28 rue du docteur Roux, 75724 PARIS Cedex 15

The student that is recruited will spend his/her time between both laboratories (INRA and Pasteur), and will have a supervisor in each laboratory. Please include both supervisors in all correspondances.

Key Words
Gallus gallus/ Mus musculus/ Intestinal Microbiota / Salmonella/ Quantitative Genetics / Immunity
Fields of quantitative genetics, pathology, microbiology

Short summary
Salmonella enterica Enteritidis is one of the main causes of food intoxications through the consumption of contaminated poultry products (meat and eggs). This bacteria is asymptomatically carried by chickens, but can infect man. Genetic selection and modulation of the intestinal microbiota are two promising methods to decrease carriage in the chicken and the propagation of salmonella on farms without using antibiotics. The objectives of this project are to identify the principal genetic and microbial factors that control individual salmonella carriage in chickens and mice. The study of a murine model for infection will accelerate the identification of genes and functions and will facilitate our experimental approach. The factors identified in two species in experimental lines will be validated in laying hen commercial lines in order to accelerate the application of the results for a rapide decrease of salmonella propagation on farms and the threat it represents for human health.