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The main challenges to which the animal science community are faced today are to use the genotype to predict phenotypes in a specific environment and to go from a small number of individuals that are highly annotated to approaches capable of generating information on gene expression and regulation on a population scale. Recent methodologies (for example, new in vitro phenotyping systems coupled with editing of genetic and epigenetic elements of the genome) will help meet these challenges to integrate knowledge on the cell, tissue and whole animal levels.

The new FAANG actions will lead to a more efficient annotation of genetic variants, in particular those that have roles in regulation, allowing for an improved priorizing of variants for a genomic selection enriched by the functional information and the development of new management systems (genome-enabled management) via prediction of phenotypes. The study at the population level will contribute to identifying, and improving the preservation and use of genomic biodiversity of breeds and populations adapted to different environments. New fundamental biology infofmation will support research in several fields including health (One-Health), systems biology, and the study of the environment. 

• Contact : elisabetta.giuffra@inrae.fr