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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal AgroParisTech Université Paris-Saclay

INRA GABI Unit

GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

Team Core facilities

Team leader: Michèle Tixier-Boichard (michele.boichard@jouy.inra.fr) Co-leaders Claudia Bevilacqua: microgenomics, qPCR Christine Longin: electron microscopy

@BRIDGe Core Facilities
© INRAE

Objectives

Photo-Equipe-Plateforme

The team includes expertise, know-how and equipments for the core facilities managed by GABI that are open to users outside of GABI;

  • The @BRIDGe Core Facilities (animal Biological Resources for Integrated and Digital Genomics, http://abridge.inra.fr);
  • The Electron transmission microscope of the MIMA2 multi-site electronic transmission microscopy imaging core facilities.

Services and equipments are proposed for the conservation of biological samples to their analysis at the molecular, cell or tissue levels.

The total number of users varies between 120 to 170 per year.

Technological services and expertise

Core facilties

Biobanking services:

  • BAC librairies: cattle, sheep, goat, horse, pig, rabbit, chicken.
  • Conditioning, secured conservation, distribution of all types of biological samples except infectious material.
  • 21 freezers at -80°C or -40°C,
  • 2 nucleic acid robot extractors: ChemagicStar, extraction on magnetic beads (x24 ou x96), QiaCube, column extractions (x12),
  • 8 instruments for the quantification and quality control of nucleic acids

@BRIDGe Genomics Services

  • Agilent Station for microarray hybridization;
  • Illumina MiSeq sequencing; Capture of targeted genomic regions;
  • Quantitative PCR: Life Technologies QuantStudio 12K Openarray and TaqMan array cards; Digital PCR for absolute quantification with a BioRad ddPCR QX200 ;
  • GeneSpring GX (Agilent) and Ingenuity Pathway (Ingenuity) analysis software for transcriptomes, GeneX (Multid) for qPCR.

Functional Analysis and Morphology at the cell and tissue levels (@BRIDGe)

  • Histology: tissue fixation, slicing and staining; in situ hybridization on cryogenized tissue sections; immunohistochemistry, light-background virtual slides.
  • A digital fluorescence/light-background scanner for virtual slides (Panoramic SCAN, 3DHistech), cassettes and slide printers (Primera), 2 ultramicrotomes (Reichert E – Leica UC6), 1 Leica immunohistochemical robot.
  • Microgenomics by Laser Microdissection: production and genomic analysis of micro-and nano-quantities of material extracted from cells isolated from their tissue environment under morphological control.
  • Laser Capture Microdissection System (ARCTURUS XT IR /UV), 2 cryostats, 1 SnapFrost.

Ultra-structural analysis of the cell and its organelles (MIMA2)

  • Electron transmission microscopy platform with 2D and 3D analysis and reconstruction with a HITACHI 7700 electron microscope.

Activities and Networks

  • The fields of activity are structural and functional genomics, microgenomics, morphological and ultra-structural analyses.
  • The biobank and its genomic and microgenomic equipment are part of the national CRB-Anim infrastructure supported by the “Future Investments” program since 2012.
  • GABI’s core facilities are part of the Jouy-en-Josas research center’s ARPEJ network.
  • @BRIDGe is a member of the GENOPS network for the Paris-Saclay genomic core facilities.

Quality certification

  • The @BRIDGe core facility is ISO 9001:2015, and NFS 96 900 certified for its biobanking activities. The biobank is approved by IBiSA and by INRAE as a Collective Scientific Infrastructure (ISC).
  • The MIMA2 core facilities is approved as an ISC by INRAE