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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Mammary Gland and Lactation Team

Team Leaders: Sandrine Le Guillou and Hervé Accloque

Expertise

Functional genomics, Physiology, Epigenetics..

Overall Activity

The GaLac team’s main objective is to improve our understanding of the factors that influence the mother-offspring continuum via milk and to decipher the molecular mechanisms involved.

Outstanding Results

An obesogenic diet has a deleterious long-term effect on the mammary gland.
The presence of microRNA in milk is correlated with their expression in the mammary gland.

Scientific Questions

We study the mammary gland, which plays a key role in milk production and composition. The study of milk provides information on the modifications of the mammary gland function and allows the identification of factors that may be responsible for phenotypic variations in young animals. Improving our understanding of the molecular mechanisms that underlie the development of the mammary gland and milk production allows us to identify levers for a better control of these. Toward these aims, we study more particularly, the environmental and genetic effects on these functions.

Objects of study:

Model species: mice, rabbits.
Livestock species: rabbits, cattle, goats, sheep.

Scale of analyses:
- Whole animal, over several generations: effects of various factors on lactation physiology and offspring growth.
- Organs: development of the mammary gland.
- Cells: differentiation of mammary epithelial cells.
- Molecules: mammary gland proteomes, transcriptomes and miRNomes, milk composition (proteins, lipids, fine phenotyping of the major milk proteins by LC-MS, miRNomes by high-throughput sequencing).

1 – Studies on the mother:

- Health: effects of mammary gland infections on lactation (by following epigenetic markers that occur during inflammation along successive lactations, study of the SOCS-2 gene mutation associated with mastitis predisposition).
- Feeds: effects of feed restrictions (study of mammary gland microRNA expression variation, identification of markers).
- Genetic variations: detection of associations between mammary gland microRNA, genetic variants and milk QTL in ruminants (cattle, goats, sheep).
- Key genes: their role in the development of the mammary gland and lactation (SOCS-2, Lpl, miR-30b, Rspo1).

2 – Studies on the mother-offspring continuum:

- Foods: effect of foods on the mother and her offspring.
- Programming: determination of critical periods (puberty, gestation and lactation) that have an effect on the future of the offspring.

3– Studies on milk:

Environment and genetic variations: effects on milk composition (analysis of modifications due to age, parity, health, foods, breed, selection), and on milk lipolysis.
- Foods: detection of xenomiR in milk.

Research Tools

M- Fine phenotyping methods of the protein fraction of milk: profiling of the major lactopro-teins combined with liquid chromatography coupled with mass spectrometry (LC-MS).
Development and access to an interactive database for all rumi-nant microRNA available in the literature: RumimiR
(http://rumimir.sigenae.org/).

Partnerships

INRAE : UMR PEGASE, Herbivores, GenPhySE and Breed.
National: Toulouse and Alfort Veterinary Schools.
International: University of Tizi-Ouzou, Algeria. University of Davis, California, USA.
Private: Actalia, CCPA, Hypharm
Breeding sector Idele

Member of the doctoral school: SDSV (Structure and Dynamics of Living Systems).

Member of the University Paris-Saclay.