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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal AgroParisTech Université Paris-Saclay SAPS - Sciences Animales Paris-Saclay


GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech


Recent publications

Abou el qassim L, Alonso J, Zhao K, Le Guillou S, Diez J, Vicente F, Fernandez-Sanjurjo M, Iglesias-Gutiérrez E, Guan L, Royo LJ. 2022. Differences in the microRNAs levels of raw milk from dairy cattle raised under extensive or intensive production systems. Veterinary Sciences. 

Dufour A, Kurilo C, Stöckl JB, Laloë D, Bailly Y, Manceau P, Martins F, Turhan AG, Ferchaud S, Pain B, Fröhlich T, Foissac S, Artus J, Acloque H. 2023. Cell specification and functional interactions in the pig blastocyst inferred from single cell transcriptomics. BioRXIV. 

Hue-Beauvais C, Bédin K, Robert R, Gardan-Salmon D, Maupin M, Brun N, Aujean E, Jaffrezic F, Simon S, Charlier M, Le Provost F. 2022. Impact of pre-breeding feeding practices on rabbit mammary gland development at mid-pregnancy Peer Community in Animal Science (bioRxiv)

Leduc A, Le Guillou S, Bianchi L, Oliveira Correia L, Gelé M, J. Pires J, Martin P, Leroux C, Le Provost F, Boutinaud M. 2022. Milk proteins as a feed restriction signature indicating the metabolic adaptation of dairy cows. Scientific report. 


Abou el qassim L, Le Guillou S, Royo LJ. 2022. Variation of miRNA Content in Cow Raw Milk Depending on the Dairy Production System. Int J Mol Sciences. 

Al Adhami H, Bardet AF, Dumas M, Cleroux E, Guibert S, Fauque P, Acloque H, Weber M. 2022. A comparative methylome analysis reveals conservation and divergence of DNA methylation patterns and functions in vertebrates. BMC Biol. 

Auzino B, Miranda G, Henry C, Krupova Z, Martini M, Salari F, Cosenza G, Ciampolini R, Martin P. 2022. Top-Down proteomics based on LC-MS combined with cDNA sequencing to characterize multiple proteoforms of Amiata donkey milk proteins. FOOD RESEARCH INTERNATIONAL.

Faulconnier Y, Boby C, Coulpier F, Lemoine S, Martin P, Leroux C. 2022. Comparative transcriptome analysis of goat (Capra hircus) adipose tissue reveals physiological regulation of body reserve recovery after the peak of lactation. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. 

Faure MC, Khoueiry R, Quanico J, Acloque H, Guerquin MJ, Bertoldo MJ, Chevaleyre C, Rame C, Fournier I, Salzet M, Dupont J, Froment P In Utero. 2021. Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood. Front Endocr 12


Aujean E, Laubier J,  Brun N, Finot L, Chanat E, Dessauge F, Hue-Beauvais C, Le Provost F. 2020. Genomic DNA PCR analysis to assess xenograft development in mouse mammary gland. BioTechniques. 68, i press

Beaujean N, Boutinaud M, Devinoy E, Jammes H, Le Guillou S, Le Provost F, Leroux C, Mobuchon L, Pannetier M, Sellem E, Kiefer H. 2020. L’épigénétique et la construction du phénotype chez le bovin. Inrae Prod Anim. 33, 109- 124

Billa PA , Faulconnier Y, Ye T, Bourdon C ,Pires JAA, Leroux C. 2021. Nutrigenomic analyses reveal miRNAs and mRNAs affected by feed restriction in the mammary gland of midlactation dairy cows. PlosOne. 16, e0248680

Bourdon C, Boussaha M, Bardou P, Sanchez MP, Le Guillou S, Tribout T, Larroque H, Boichard D, Rupp R, Le Provost F, Tosser-Klopp G. 2021. In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets. Scient Report. 11 

Hue-Beauvais C, Faulconnier Y, Charlier M, Leroux C. 2021. Nutritional Regulation of Mammary Gland Development and Milk Synthesis in Animal Models and Dairy Species. Genes. 12, 523

Ivanova E, Le Guillou S, Hue-Beauvais C, Le Provost F. 2021. Epigenetics: New Insights into Mammary Gland Biology. Genes. 12, 231

Pawlowski K, Lago‑Novais D, Bevilacqua C, Mobuchon L, Crapart N, Faulconnier Y, Boby C, Carvalho G, Martin P, Leroux C. 2020. Different miRNA contents between mammary epithelial cells and milk fat globules: a random or a targeted process? Mol Biol Rep. early access

Tartaglia NR, Nicolas A, Rodovalho VD, da Luz BSR, Briard-Bion V, Krupova S, Thierry A, Coste F, Burel A, Martin P, Jardin J, Azevedo V, Le Loir Y, Guedon E. 2020. Extracellular vesicles produced by human and animal Staphylococcus aureus strains share a highly conserved core proteome. Sci Rep. 10, 846


Billa PA, Faulconnier Y, Ye T, Chervet M, Le Provost F, Pires JAA, Leroux C. 2019. Deep RNA-Seq reveals miRNome differences in mammary tissue of lactating Holstein and Montbeliarde cows. BMC Genomics. 20, 621

Bourdon C, Bardou P, Aujean E, Le Guillou S, Tosser-Klopp G, Le Provost F. 2019. RumimiR: a detailed microRNA database focused on ruminant species. Database Oxford. 2019, baz099

Fang ZH, Bovenhuis H, van Valenberg HJF, Martin P, Duchemin SI, Huppertz T, Visker MHPW. 2019. Genome-wide association study for alpha(S1)- and()alpha(S2) -casein phosphorylation in Dutch Holstein Friesian. J Dairy Sci. 102, 1374-1385

Hue-Beauvais C, Aujean E, Miranda G, Ralliard-Rousseau D, Valentino S, Brun N, Ladebese S, Pechoux C, Chavatte-Palmer P, Charlier M. 2019. Impact of exposure to diesel exhaust during pregnancy on mammary gland development and milk composition in the rabbit. PLoS One, 14-e0212132 

Le Guillou S, Laubier J, Pechoux C, Aujean E, Castille J, Leroux C, Le Provost F. 2019. Defects of the endoplasmic reticulum and changes to lipid droplet size in mammary epithelial cells due to miR-30b-5p overexpression are correlated to a reduction in Atlastin 2 expression. Biochem Biophys Res Commun. 512, 283-288

Miranda G, Bianchi L, Krupova Z, Trossat P, Martin P. 2020. An improved LC-MS method to profile molecular diversity and quantify the six main bovine milk proteins, including genetic and splicing variants as well as post-translationally modified isoforms. Food Chem X. 5, 100080

Ryskaliyeva A, Henry C, Miranda G, Faye B, Konuspayeva G, Martin P. 2019. The main WAP isoform usually found in camel milk arises from the usage of an improbable intron cryptic splice site in the precursor to mRNA in which a GC-AG intron occurs. BMC Genet. 20, 14

Ryskaliyeva A, Henry C, Miranda G, Faye B, Konuspayeva G, Martin P. 2019. Alternative splicing events expand molecular diversity of camel CSN1S2 increasing its ability to generate potentially bioactive peptides. Sci Rep. 9, 524

Ryskaliyeva A, Krupova Z,Henry C, Faye B, Konuspayeva G, Martin P. 2019. Comprehensive proteomic analysis of camel milk-derived extracellular vesicles. Int J Biol Chem. 12, 93-104


Burute M, Prioux M, Blin G, Truchet S, Letort G, Tseng Q, Bessy T, Lowell S, Young J, Filhol O, Théry M. 2017. Polarity reversal by centrosome repositioning primes cell scattering during epithelial-to-mesenchymal transition. Dev Cell. 40, 168-184

Cherbuy C, Vaugelade P, Labarthe S, Honvo-Houeto E, Darcy-Vrillon B, Watford M, Duée PH. 2017. The contribution of intestinal gluconeogenesis to glucose homeostasis is low in 2-day-old pigs. J Nutr. 147, 361-366

Demazeau G, Plumecocq A, Lehours P, Martin P, Couedelo L, Billeaud C. 2018. A new high hydrostatic pressure process to assure the microbials safety of human milk while preserving the biological activity of its main components. Front Public Health. 6, 306

Durcin M, Fleury A, Taillebois E, Hilairet G, Krupova Z, Henry C, Truchet S, Trötzmüller M, Köfeler H, Mabilleau G, Hue O, Andriantsitohaina R,  Martin P, Le Lay S. 2017. Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles. J Extracell Vesicles. 6, 1305677.

Hue-Beauvais C, Miranda G, Aujean E, Jaffrezic F, Devinoy E, Martin P, Charlier M. 2017. Diet-induced modifications to milk composition have long-term effects on offspring growth in rabbits. J Anim Sci. 95, 761-770

Rainard P, Gitton C, Chaumeil T, Fassier T, Huau C, Riou M, Tosser-Klopp G, Krupova Z, Chaize A,  Gilbert FB, Rupp R, Martin P. 2018. Host factors determine the evolution of infection with Staphylococcus aureus to gangrenous mastitis in goats. Vet Res, 49-72

Ryskaliyeva A, Henry C, Miranda G, Faye B, Konuspayeva G, Martin P. Combining different proteomic approaches to resolve complexity of the milk protein fraction of dromedary, Bactrian camels and hybrids, from different regions of Kazakhstan. PLoS One. 13-e0197026.

Vanbergue E, Peyraud JL, Ferlay A, Miranda G, Martin P, Hurtaud C. 2018. Effects of feeding level, type of forage and milking time on milk lipolytic system in dairy cows. Livest Sci. 217, 116-12


Chadi S, Polyte J, Lefevre L, Castille J, Ehanno A, Laubier J, Jaffrézic F, Le Provost F. 2016. Phenotypic and molecular alterations in the mammary tissue of R-spondin1 knock-out mice during pregnancy. PLoS One. 11, e0162566

Honvo-Houéto E, Henry C, Chat S, Layani S, Truchet S. 2016. The endoplasmic reticulum and casein-containing vesicles contribute to milk fat globule membrane. Mol Biol Cell. 27, 2946-2964

Montazer-Torbati F, Boutinaud M, Brun N, Richard C, Neveu A, Jaffrézic F, Laloë D, LeBourhis D, Nguyen M, Chadi S, Jammes H, Renard JP, Chat S, Boukadiri A, Devinoy E. 2016. Differences during the first lactation between cows cloned by somatic cell nuclear transfer and non-cloned cows. J Dairy Sci. Preaccepted

Pauloin A, Adenot P, Hue Beauvais C, Chanat E. 2016. The perilipin-2 (adipophilin) coat of cytosolic lipid droplets is regulated by an Arf1-dependent mechanism in HC11 mouse mammary epithelial cells. Cell Biol Int. 40, 143-155

Valentino SA, Tarrade A, Aioun J, Mourier E, Richard C, Dahirel M,Rousseau-Ralliard D, Fournier N,  Aubrière MC, Lallemand MS, Camous S, Guinot M, Charlier M, Aujean E, Al Adhami H, Fokkens PH, Agier L, Boere JA, Cassee FR, Slama R, Chavatte-Palmer P. 2016. Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits. Part Fibre Toxicol. 13, 39

Previous publications

Baco M, Chu C, Chiang Y, Marthey S, Le Provost F, Chu C, Vincent-Naulleau S. 2013. Identification of microRNAs involved in the spontaneous regression of cutaneous melanoma in pigs. J Invest Dermatol. 133, S223. Meeting abstract.

Baco M, Yang YT, Marthey S, Chiang YS, Chu CY, Leprovost F, Chu CY, Vincent-Naulleau S. 2013. miRNAs Profile of Cutaneous Melanoma Undergoing Complete Spontaneous Regression in MeLiM Pigs.    JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT. 11, 46-47. Meeting abstract

Desjardin C, Vaiman A, Mata X, Legendre R, Laubier J, Kennedy SP, Laloe D, Barrey E, Jacques C, Cribiu EP, Schibler L. 2014. Next-generation sequencing identifies equine cartilage and subchondral bone miRNAs and suggests their involvement in osteochondrosis physiopathology. BMC Genomics. 15, 798

Henry C, Saadaoui B, Bouvier F, Cébo C. 2015. Phosproteomics of the goat milk fat globule membrane: new insights into lipid droplet secretion from the mammary epithelial cell. Proteomics. 15, 2307-2317

Honvo-Houéto, E., Truchet, S. 2015. Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland. J. Vis. Exp. (106), e53179

Hue-Beauvais C, Koch E, Chavatte Palmer P, Galio L, Chat S, Letheule M, Rousseau Ralliard D, Jaffrezic F, Laloë D, Aujean E, Révillion F, Lhotellier V, Gertler A, Devinoy E, Charlier M. 2015. Milk from dams fed an obesogenic diet combined with a high-fat/high-sugar diet induces long-term abnormal mammary gland development in the rabbit. J Anim Sci. 93, 1641-1655

Laubier J, Castille J, Le Guillou S, Le Provost F. 2015. No transfer of diet-derived microRNAs from mouse milk to pup tissues. RNA Biol. 12, 26-29

Le Guillou S, Marthey S, Laloë D, Laubier J, Domagalski J, Mobuchon L, Leroux C, Le Provost F. 2014. Identification and comparison of lactating mouse and bovine mammary gland miRNomes. Plos One. 9, e91938

Le Parc A, Dallas DC, Duaut S, Leonil J, Martin P, Barile D. 2014. Characterization of goat milk lactoferrin N-glycans and comparison with the N-glycomes of human and bovine milk. Electrophoresis 35, 1560-1570

Le Parc A, Honvo-Houéto E, Pigat N, Chat S, Leonil J, Chanat E. 2014. The membrane-associated form of as1-casein interacts with cholesterol-rich detergent-resistant microdomains. PLoS ONE . 9, e115903

Leroux C, Bernard L, Dessauge F, Le Provost F, Martin P. 2013. The function of lactation: regulation of biosynthesis of the milk components. INRA Productions Animales 26, 117-128

Mobuchon L, Marthey S, Boussaha M, Le Guillou S, Leroux C, Le Provost F. 2015. Annotation of the goat genome using next generation sequencing of microRNA expressed by the lactating mammary gland: comparison of three approaches. BMC Genomics. 16, 285

Mobuchon L, Marthey S, Le Guillou S, Laloë D, Le Provost F, Leroux C. 2015. Food deprivation affects the miRNome in the lactating goat mammary gGland. PLoS One. 10, e0140111

Nguyen M, Boutinaud M, Pétridou B, Gabory A, Pannetier M, Chat S, Bouet S, Jouneau L, Jaffrezic F, Laloë D, Klopp C, Brun N, Kress C, Jammes H, Charlier M, Devinoy E. 2014. DNA Methylation and Transcription in a Distal Region Upstream from the Bovine AlphaS1 Casein Gene after Once or Twice Daily Milking. PLoS ONE. 9, e111556

Petridou B. 2015. Differences in affinities between the homologous and the heterologous rabbit prolactin-receptor interaction with respect to proliferation and differentiation activities. Gen Comp Endocr. 213, 118-129

Truchet S, Chat S, Ollivier-Bousquet M. 2014. Milk Secretion: The role of SNARE proteins. J Mammary Gland Biol  Neoplasia. 19, 119-130