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INRA
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31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal AgroParisTech Université Paris-Saclay

INRA GABI Unit

GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

Commercialization of a genotyping test for the curly hair coat phenotype in the curly breed in the horse

INRAE Gene test curly hair coat Curly breed
A new genotyping test allows the identification of which sires will produce Curly foals with a curly hair coat that has the reputation of being less allergenic for allergic riders.

MOTS-CLES : horse; genetics; genotyping ; danders; keratin

Illustrations issues de l’article Morgenthaler et al. (2017), Genetics Selection Evolution, 49(1), 85

Illustrations issues de l’article Morgenthaler et al. (2017), Genetics Selection Evolution, 49(1), 85

* Illustration

Horses of the Curly breed have a curly hair coat. This particularity is due to a mutation of keratin 25 (KRT25) idzentified by the team. The structure of this curly hair gives the Curly breed its reputation of being hypoallergenic.

 

Indeed, curly hair retains dander and dust, which makes the manipulation of these horses more "pleasant" for those allergic to horse hair. A genotyping test for this mutation is now proposed by LABEO Frank Duncombe (Caen, France), which allows breeders to plan reasoned matings in order to produce foals that carry this commercially advantageous trait. This application was developed following the publication of the KRT25 mutation, and after additional work by the team on the development of a genotyping test that is rapid, reliable and usable in routine by laboratories for veterinary analyses.

INRA transfert and the laboratory LABEAO Franck Duncombe (Caen) just signed a license for a genotyping test for the curly hair trait in Curly breed horses.  This genotyping test of the "curly hair" mutation will be useful to breeders of these horses to genotype stallions and mares so that they may plan reasoned matings and produce foals with a curly hair coat, which will be better valorized as leisure horses.

This genotyping test is available to all horse breeders: a genotyping service is now offered by the LABEO Frank Duncombe Laboratory (Caen).
  

Contact(s)

Scientific Contact:

Division: Animal Genetics

Research Center : Jouy-en-josas

 

#3Perf

INRA Priority in its Guidance Document

#3Perf-2: Using biology and technology techniques for multiperformance

*Illustration (Illustration from the article published by Morgenthaler et al. (2017), Genetics Selection Evolution, 49(1), 85)
Figure : A large variaiblity exists of curly hair types in Curly horses. The only constant is curliness (more or less curly) of hair coat, ears (image b), which may be used to recognize a Curly horse when its horsehair is only slightly wavy (image e). Hair coat may have a minimum amount of curliness or a very dense "tight" curls "micro curls" (g image), or anything in between including wavy "marcel" type curls. Curliness similarities exist with the Rex phenotype in cats and are considered "extreme" in horses. Tail horsehair (image C) and mane (image d) may also have different types of curliness going from a waviness to real curls which sometimes ressemble "dreadlocks".

See also

Valorization: Licence exclusive de savoir-faire concédée au laboratoire LABEO Frank Duncombe, laboratoire d’analyse vétérinaires à Caen.
Bibliography:
Morgenthaler, C., Diribarne, M., Capitan, A., Legendre, R., Saintilan, R., Gilles, M., … Cothran, G. (2017). A missense variant in the coil1A domain of the keratin 25 gene is associated with the dominant curly hair coat trait (Crd) in horse. Genetics Selection Evolution, 49(1), 85. http://doi.org/10.1186/s12711-017-0359-5
S. Dhorne-Pollet ; C. Morgenthaler ; F. Cesarin ; A. Debus; C. Robert et E. Barrey. (2019) Test de génotypage du caractère frisé chez le cheval de race Curly. Journée Sciences & Innovations Equines, 23&24 Mai 2019, Saumur.