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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal AgroParisTech Université Paris-Saclay

INRA GABI Unit

GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

BovReg - Identification of functionally active genomic features relevant to phenotypic diversity and plasticity in cattle.

BovReg
The scientific project is focused on "Identification of functionally active genomic features relevant to phenotypic diversity and plasticity in cattle."

Despite the revolution in functional genome analysis a wide gap in understanding associations between the (epi)genome and complex phenotypes of interest currently remains and impedes efficient use of annotated genomes for precision breeding. The BovReg consortium will provide a comprehensive map of functionally active genomic features in cattle and how their (epi)genetic variation in beef and dairy breeds translates into phenotypes. This constitutes key knowledge for biology-driven genomic prediction needed by scientific and industry livestock communities. The BovReg brings together a critical mass of experts in ruminant research and beyond encompassing bioinformatics, molecular and quantitative genetics, animal breeding, reproductive physiology, ethics and social science. Our 20 partners from the EU, Canada and Australia form a global interdisciplinary team, which builds on previous and running national and EU-funded projects and many established industry cooperations. In BovReg we will generate functional genome data based on FAANG core assays from representative bovine tissues and newly established cell lines covering different ontological stages and phenotypes applying novel bioinformatic pipelines. We will establish detailed knowledge on traits related to robustness, health and biological efficiency in cattle. Data, knowledge and protocols will be deposited in European biological archives, aiming to set up and maintain a knowledge hub and establish gold standards. Long-term availability of data and targeted dissemination and communication activities are guaranteed by EMBL-EBI, FAANG and EAAP. Our biology-driven genomic prediction tools will integrate biological knowledge on regulatory genomic variation into genomic selection schemes for local and global cattle populations. This improved knowledge will be useful for re-focussing cattle production, fully taking into account societal awareness, environmental and animal-welfare aspects and bio-efficiency.

Financing CE H2020

Programme(s)

Theme(s): SFS-30-2018-2019-2020 - Agri-Aqua Labs

Call for projects: H2020-SFS-2018-2

Funding regime: RIA - Research and Innovation action

Period: 1 September 2019 - 31 August 2023

Coordination: LEIBNIZ-INSTITUT FUR NUTZTIERBIOLOGIE (Allemagne)

18 Partner Consortium
FUNDACIO CENTRE DE REGULACIO GENOMICA (Espagne), INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT (France), DIAGENODE (Belgique), UNIVERSITE DE LIEGE (Belgique), EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH (Suisse), STICHTING WAGENINGEN RESEARCH (Pays-Bas), AARHUS UNIVERSITET (Danemark), LUONNONVARAKESKUS (Finlande), (
INSTYTUT GENETYKI I HODOWLI ZWIERZAT POLSKIEJ AKADEMII NAUK (Pologne), UNIVERSITEIT UTRECHT (Pays-Bas), EUROPEAN MOLECULAR BIOLOGY LABORATORY (Allemagne), FEDERAZIONE EUROPEA DI ZOOTECNICA (Italie), THE GOVERNORS OF THE UNIVERSITY OF ALBERTA UNIVERSITY OF ALBERTA (Canada), THE UNIVERSITY OF EDINBURGH (Royaume-Uni), MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG (Allemagne),UNIVERSITE DE LIMOGES (France), FACULDADE DE MEDICINA VETERINARIA (Portugal), EDINETHICS LIMITED (Royaume-Uni)

Scientific Leader: Dominique Rocha (UMR GABI, G2B Team) - dominique.rocha@inrae.fr