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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal AgroParisTech Université Paris-Saclay


GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

Céline Bourdon will defend her PhD dissertation via video conferencing on Monday March 15 at 9.30

15 March 2021

Asociation between microRNA genetic variants and dairy QTL in bovine, caprine and ovine species

Céline Bourdon will defend her PhD dissertation entitled "Association between microRNA genetic variants and dairy QTL in bovine, caprine and ovine species" on Monday March 15 at 9.30 by video conference.

Jury members:

M. Juan José ARRANZ                  University of Leon                        Reporter

Mme Christine GASPIN                INRAE - UMR MIAT                       Reporter

Mme Rozenn DALBIES-TRAN      INRAE - UMR PRC                          Examinator

Mme Christine LEROUX               INRAE - UMR Herbivores             Examinator

M. Bernard MIGNOTTE                Université Paris Saclay                 Examinator

Mme Fabienne LE PROVOST       INRAE – UMR GABI                       PhD Advisor

Mme Gwenola TOSSER-KLOPP   INRAE - UMR GenPhySE               PhD co-Adivsor

Key-words: dairy QTL, microARN, Genetic Variants


Genomic selection, based on the prediction of the genetic value of candidate animals based on the information provided by a large number of genetic markers using neutral markers, is a relevant and perennial lever. The search for causal mutations and their integration into genomic evaluations would allow a significant gain in precision. It is therefore essential to better characterize the causal mutations responsible for the variability of quantitative traits related to production efficiency and the quality of products such as milk. The objective of this project has been to search for genetic variants of microRNA expressed in the mammary gland or present in milk and located in genomic regions having an effect on dairy and mastitis quantitative traits (QTL), in three ruminant species. The detection of 59,124 microRNA variants expressed in the mammary gland or present in milk in cattle, 13,427 variants in goats and 4,761 in sheep has been allowed through the development of a bioinformatics script.    In cattle, 4,679 genetic variants of interest have been located in dairy and mastitis QTLs and 127 in goats, none in sheep. Three detected bovine variants have been validated through GWAS studies. The biological effects of the validated variants have been studied, with different strategies depending on the location and thus the putative effect of the mutation. For the mutation located in the "seed" region of bta-let-7e, the expression level of targeted mRNA has been tested. Inconsistent results were obtained between the qRT-PCR and RNAseq techniques used. For mutations located in the flanking regions of bta-miR-92b and bta-miR-486, the presence of these microRNA has been measured in bovine milk. These analyses did not reveal any significant difference in the expression of microRNA between genotypes. This project therefore has allowed a global analysis of microRNA variants, from their detections to their potential effects.