Know more

About cookies

What is a "cookie"?

A "cookie" is a piece of information, usually small and identified by a name, which may be sent to your browser by a website you are visiting. Your web browser will store it for a period of time, and send it back to the web server each time you log on again.

Different types of cookies are placed on the sites:

  • Cookies strictly necessary for the proper functioning of the site
  • Cookies deposited by third party sites to improve the interactivity of the site, to collect statistics

Learn more about cookies and how they work

The different types of cookies used on this site

Cookies strictly necessary for the site to function

These cookies allow the main services of the site to function optimally. You can technically block them using your browser settings but your experience on the site may be degraded.

Furthermore, you have the possibility of opposing the use of audience measurement tracers strictly necessary for the functioning and current administration of the website in the cookie management window accessible via the link located in the footer of the site.

Technical cookies

Name of the cookie

Purpose

Shelf life

CAS and PHP session cookies

Login credentials, session security

Session

Tarteaucitron

Saving your cookie consent choices

12 months

Audience measurement cookies (AT Internet)

Name of the cookie

Purpose

Shelf life

atid

Trace the visitor's route in order to establish visit statistics.

13 months

atuserid

Store the anonymous ID of the visitor who starts the first time he visits the site

13 months

atidvisitor

Identify the numbers (unique identifiers of a site) seen by the visitor and store the visitor's identifiers.

13 months

About the AT Internet audience measurement tool :

AT Internet's audience measurement tool Analytics is deployed on this site in order to obtain information on visitors' navigation and to improve its use.

The French data protection authority (CNIL) has granted an exemption to AT Internet's Web Analytics cookie. This tool is thus exempt from the collection of the Internet user's consent with regard to the deposit of analytics cookies. However, you can refuse the deposit of these cookies via the cookie management panel.

Good to know:

  • The data collected are not cross-checked with other processing operations
  • The deposited cookie is only used to produce anonymous statistics
  • The cookie does not allow the user's navigation on other sites to be tracked.

Third party cookies to improve the interactivity of the site

This site relies on certain services provided by third parties which allow :

  • to offer interactive content;
  • improve usability and facilitate the sharing of content on social networks;
  • view videos and animated presentations directly on our website;
  • protect form entries from robots;
  • monitor the performance of the site.

These third parties will collect and use your browsing data for their own purposes.

How to accept or reject cookies

When you start browsing an eZpublish site, the appearance of the "cookies" banner allows you to accept or refuse all the cookies we use. This banner will be displayed as long as you have not made a choice, even if you are browsing on another page of the site.

You can change your choices at any time by clicking on the "Cookie Management" link.

You can manage these cookies in your browser. Here are the procedures to follow: Firefox; Chrome; Explorer; Safari; Opera

For more information about the cookies we use, you can contact INRAE's Data Protection Officer by email at cil-dpo@inrae.fr or by post at :

INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal AgroParisTech Université Paris-Saclay

INRA GABI Unit

GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

Eric Barrey, Senior Research Scientist

BARREY Eric
Topics: Equine Genomics, muscular and mitochondrial functional genomics, miRNA and mitochondria crosstalk with the nuclear genome

INRA, UMR 1313 Génétique Animale et Biologie Intégrative
Domaine de Vilvert, Bat 211, 78352 Jouy en Josas
Tel : +33 (0) 1 34 65 29 53   Fax  : +33 (0) 1 34 65 22 10

Email :eric.barrey@inrae.fr

Research unit: Animal Genetics and Integrative Biology (GABI)

Research Team: Integrative Biology and Equine Genetics (BIGE)

Track record

My clinician background is strengthened with knowledge on integrative of biology in exercise physiology, quantitative genetics and genomics. My scientific career has taken atypical paths allowing an integrative biology approach of functional genomics in muscular exercise in order to progress in animal and human health.

• Outstanding Position (2013): Research Director, Team leader of Integrative Biology and Equine Genetics (BIGE), INRA, Jouy-en-Josas, France.

• 2004-2013: Team leader of functional genomics in muscular exercise, Laboratory of Integrative Biology of Exercise Adaptations (UBIAE), Inserm U902, Genopole, Université d'Evry Val d’Essone, 91025 Evry, France.

• 1990-2004: Research Associate at the Animal Genetics Department (Station de Génétique Quantitative et Appliquée,  Team of Equine genetics), INRA, Jouy-en-Josas, France.

• 1987-90: PhD and Assistant in the Nutrition and Exercise Laboratory of the Veterinary School of Alfort (ENVA), France.

• 1987-90: PhD Thesis, ENSAM, Paris. 1st Price of the French Biomechanics Society.

• 1987: Doctor in Veterinary Medicine (DVM), Alfort Veterinary School (DVM)

Fields of Research

Since 2004 my main research objective was to study muscular functional genomics in normal, pathological or treated muscle. Genomic functional disorders in two equine myopathies PSSM and RER were explored using expression microarrays and data mining methods.

In 2011, a scientific breakthrough in mitochondrial crosstalk was the discovery of pre-microRNAs and mature miRNAs encoded by the nuclear genome localized in mitochondria of human myocytes and the in silico prediction of putative miRNA sequences and targets on mtDNA. The paper has been published in PlosOne 2011:

Barrey E, Saint-Auret G, Bonnamy B, Damas D, Boyer O, Gidrol X. (2011) Pre-microRNA and mature microRNA in human mitochondria.PLoS One. 2011;6(5):e20220.

The metrics today indicated more than 15000 views, 42 citations. The results of this paper were confirmed by several other papers and new regulation functions of several miRNA localized to mitochondrial has been discovered. Recently, two miRNAs encoded  by the mitochondrial genome and derived from the 16S transcript were identified.  Other putative miRNAs derived from mtDNA transcription are studied in our team.   

Other Activites

Chaiman of international  conferences:

• 2002-2006: Chairman of the 7th International conference on equine exercise physiology, ICEEP 7, Fontainebleau, France, 26-31 August 2006. Peer reviewed proceedings published in Equine Vet. Journal.

• 1996: Chairman of the 3rd International Workshop on Animal Locomotion (IWAL 3) and editor of the peer reviewed proceedings published in Equine Vet. Journal.

• 1998-2010: Member of the international scientific committee of the 5th, 6th, 7th, 8th International conference on equine exercise physiology in Japan, Kentucky (USA) and South Africa, respectively.

Innovation, transfer and consulting:

An original gait analysis systems based on body 3-dimensional acceleration measurements and softwares for automatic  gait analysis has been developped at INRA in the 90's for phenotyping horses exercise ability (Equimetrix®). A technological transfer has been performed for human medical and sports applications (Locometrix®). Medical applications in neurology, rehabilitation, geriatrics, rheumatology, physiotherapy and sport medicine are used in hospitals, rehabilitation centres in Europe. Locometrix® is used in ongoing clinical trials in myology. Co-founder and scientific consultant of Centaure Metrix, a start-up company lauched in 2001.

Publications

Patents:

• 2001: Procédé d’analyse d’irrégularité de locomotion humaine: French Patent N°FR 2804596; European Patent N°EP 1261279B1; Canada N° 2,399,182; Method for analyzing irregularities in human locomotion: USA Patent N° P 680 079 US0; Centaure Metrix SAS have the exclusive license of the patents since 2001. More than 140 units were sold in Europe.

• 1989: Plaque orthopédique de maréchalerie pour sabot de cheval . French Patent N°89 01233. Damping pads to reduce the high frequency shocks that distroy articular cartilages in equine athletes. 1st Price Biochance from Lille district. Exclusive license of the patent was used during 20 years by a French chemical company Saint Gobain SA. About one million damping pads were sold to prevent digital arthrosis in sport horses.

Book chapters:

Barrey E (2012). Chapter 21: Genetics and genomics of equine athletes, In Hinchcliff, Kaneps & Geor (Eds). Equine Sports and Surgery, Elsevier, Oxford (2nd edition).

Barrey E (2012). Chapter 12: Biomechanics of locomotion in athletic horse, In Hinchcliff, Kaneps & Geor (Eds). Equine Sports and Surgery, Elsevier, Oxford (2nd edition).

BARREY E., (2001). Inter-limb coordination. In BACK W., CLAYTON H. (Eds.), "Equine locomotion", 77-94, W.B. Saunders.

BARREY E., (2000). Métodos de analisis de la locomocion equina: uso de acelerometros. In RIVERO J.L.L., "Locomocion del caballo. Métodos de analisis. Evaluacion funcional. Diagnostico de cojeras", 15-80, Universidad de Cordoba, Servicio de Reprografia, Cordoba, Spain.

SAASTAMOINEN M.T., BARREY E. (2000). Genetics of conformation, locomotion and physiological traits. In BOWLING A.T., RUVINSKY A. (Eds.), "The genetics of the horse", 439-472, CAB International, Oxon, UK.

Omics and muscular exercise

Le Moyec L, Robert C, Triba MN, Billat VL, Mata X, Schibler L, Barrey E. Protein catabolism and high lipid metabolism associated with long-distance exercise are revealed by plasma NMR metabolomics in endurance horses. PLoS One. 2014 Mar 21;9(3):e90730. doi: 10.1371/journal.pone.0090730.eCollection 2014.

Desjardin C, Vaiman A, Mata X, Legendre R, Laubier J, Kennedy SP, Laloe D, Barrey E, Jacques C, Cribiu EP, Schibler L. Next-generation sequencing identifies equine cartilage and subchondral bone miRNAs and suggests their involvement in osteochondrosis physiopathology. BMC Genomics. 2014 Sep 17;15:798. doi: 10.1186/1471-2164-15-798.

Mille-Hamard L, Billat VL, Henry E, Bonnamy B, Joly F, Benech P, Barrey E. Skeletal muscle alterations and exercise performance decrease in erythropoietin-deficient mice: a comparative study. BMC Med Genomics. 2012 Jun 29;5:29. doi: 10.1186/1755-8794-5-29.

Barrey E, Saint-Auret G, Bonnamy B, Damas D, Boyer O, Gidrol X. (2011) Pre-microRNA and mature microRNA in human mitochondria. PLoS One. 2011;6(5):e20220.

Bandiera S, Barrey E, Ernoult-Lange M, Gidrol X, Henrion-Caude A, Huang L, Saint-Auret G, Weil D (all authors had the same contribution to this review) (2012). News - La mitochondrie : un nouvel acteur de la régulation par ARN interférence. Medecine/Sciences  28, 15-17. IF 0.64.

Barrey E, Jayr L, Mucher E, Gospodnetic S, Joly F, Benech P, Alibert O, Gidrol X, Mata X, Vaiman A, Guérin G (2011) Muscular transcriptomic analysis in horses suffering from recurrent exertional rhabdomyolysis revealed energetic pathway alterations and disruption in the cytoplasmic calcium regulation. Animal Genetics (online: 27 SEP 2011 | DOI: 10.1111/j.1365-2052.2011.02246.x) IF 2.203.

Barrey E, Bonnamy B, Barrey EJ, Mata X, Chaffaux S and Guerin G (2010) Muscular microRNA expressions in healthy and myopathic horses suffering from polysaccharide storage myopathy or recurrent exertional rhabdomyolysis. Equine Vet. J. (2010) 42 (Suppl. 38) 303-310. IF 1.799; cited 3.

Capomaccio S, Cappelli K, Barrey E, Felicetti M, Silvestrelli M, Verini-Supplizi A. Microarray analysis after strenuous exercise in peripheral blood mononuclear cells of endurance horses. Anim Genet. 2010 Dec;41 Suppl 2:166-75. doi: 10.1111/j.1365-2052.2010.02129.x.

Barrey E, Mucher E, Jeansoule N, Larcher T, Guigand L, Herszberg B, Chaffaux S, Guérin G, Mata X, Benech P, Canale M, Alibert O, Maltere P, Gidrol X (2009). Gene expression profiling in equine polysaccharide storage myopathy revealed inflammation, glycogenesis inhibition, hypoxia and mitochondrial dysfunctions. BMC Vet Res. Aug 7;5:29. PubMed Central PMCID:PMC2741442. IF 2.371; cited 7.

Barrey E, Mucher E, Robert C, Amiot F, Gidrol X (2006). Gene expression profiling in blood cells of endurance horses completing competition or disqualified due to metabolic disorder. Equine Vet J Suppl. 36: 43-9. IF ; IF 1.799; cited 17.

Mucher E, Jayr L, Rossignol F, Amiot F, Gidrol X, Barrey E (2006). Gene expression profiling in equine muscle tissues using mouse cDNA microarrays. Equine Vet J Suppl. 36: 359-64. IF 1.799; cited 8.

Integrative biology

López-Sanromán FJ, Holmbak-Petersen R, Santiago I, Gómez de Segura IA, Barrey E (2011). Gait analysis using 3D accelerometry in horses sedated with xylazine. Vet J  Nov 12.  IF 2.644.

Cottin F, Metayer N, Goachet Ag, Julliand V, Slawinski J, Billat V And Barrey E (2010). Oxygen consumption and gait variables of Arabian endurance horses measured during a field exercise test. Equine Vet J  42 (Suppl. 38) 1-5. IF 1.799.

Leprêtre PM, Metayer N, Giovagnoli G, Pagliei E, Barrey E (2009). Comparison of analyses of respiratory gases made with the K4b2 portable and Quark laboratory analysers in horses. Vet Rec 165(1):22-5. IF 1.482; cited 1.

Le Bris R, Billat V, Auvinet B, Chaleil D, Hamard L, Barrey E (2006). Effect of fatigue on stride pattern continuously measured by an accelerometric gait recorder in middle distance runners. J Sports Med Phys Fitness 46 (2): 227-31. IF 0.80; cited 6.

Leleu C, Bariller F, Cotrel C, Barrey E (2004). Reproducibility of a locomotor test for trotter horses. Vet J  168:160-6. IF 2.644; cited 4.

Leleu C, Gloria E, Renault G, Barrey E (2002). Analysis of trotter gait on the track by accelerometry and image analysis. Equine Vet J Suppl. 34: 344-8. IF 1.799; cited 1.

Innovation & transfer

Mignardot JB, Deschamps T, Barrey E, Auvinet B, Berrut G, Cornu C, Constans T, de Decker L. Gait disturbances as specific predictive markers of the first fall onset in elderly people: a two-year prospective observational study. Front Aging Neurosci. 2014 Feb 25;6:22. doi: 10.3389/fnagi.2014.00022. eCollection 2014.

Barthélémy I, Barrey E, Aguilar P, Uriarte A, Le Chevoir M, Thibaud JL, Voit T, Blot S, Hogrel JY. Longitudinal ambulatory measurements of gait abnormality in dystrophin-deficient dogs. BMC Musculoskelet Disord. 2011 Apr 13;12:75. doi: 10.1186/1471-2474-12-75.

Barthélémy I, Barrey E, Thibaud JL, Uriarte A, Voit T, Blot S, Hogrel JY. Gait analysis using accelerometry in dystrophin-deficient dogs. Neuromuscul Disord. 2009 Nov;19(11):788-96. doi: 10.1016/j.nmd.2009.07.014. Epub 2009 Oct 1.

López-Sanromán FJ, Holmbak-Petersen R, Santiago I, Gómez de Segura IA, Barrey E. Gait analysis using 3D accelerometry in horses sedated with xylazine. Vet J. 2012 Jul;193(1):212-6. doi: 10.1016/j.tvjl.2011.10.012. Epub 2011 Nov 13.

Auvinet B, Bileckot R, Alix AS, Chaleil D, Barrey E (2006) Gait disorders in patients with fibromyalgia. Joint Bone Spine. Oct;73(5):543-6. Epub 2006 Mar 15. IF 2.460; cited 15.

Paquet JM, Auvinet B, Chaleil D, Barrey E (2003) Analysis of gait disorders in Parkinson's disease assessed with an accelerometer. Rev Neurol (Paris). 2003 Sep;159(8-9):786-9. IF 0.61; cited 5.

Auvinet B, Berrut G, Touzard C, Moutel L, Collet N, Chaleil D, Barrey E (2002). Reference data for normal subjects obtained with an accelerometric device. Gait & Posture 16(2): 124-34. IF 2.936; cited 92.