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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal AgroParisTech Université Paris-Saclay

INRA GABI Unit

GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

Fabienne LE PROVOST, Senior Research Scientist

Leader of the "Mammary Gland and Lactation" team (GaLac)

Fabienne Le Provost
© INRAE
My research projects are aimed at better understanding the environmental and genetic factors that have an influence on the mother-offspring continuum via milk and to decode the associated molecular mechanisms. To do this, I study, on the one hand, the mammary gland whose establishment plays a key role in milk production, and on the other hand, the composition of milk, the central element of this continuum.

 

INRAE UMR 1313 Génétique Animale et Biologie Intégrative
Domaine de Vilvert, Bat 440, 78352 Jouy en Josas
Tel : +33 (0) 1 34 65 25 69
Email : fabienne.le-provost(at)inra.fr
ORCID : 0000-0002-0588-5333

Research Team: leader of the Mammary Gland and Lactation Team (GaLac)

Diplômes

  • Nov 2010  HDR (accreditation for directing research). Université Versailles-Saint Quentin.
  • Mai 2004   Animal experimentation certification Level I. Ecole Nationale Vétérinaire, Maisons-Alfort.
  • 1991-1995 PhD in Developmental molecular and cellular biology. Université Paris XI, Orsay.

Career at INRAE

1995 Junior research scientist (2nd class)

        Biochemical Genetics and Cytogenetics Laboratory (INRA, Jouy-en-Josas).

2000-2001 Long-term mission

        Laboratory Physiology and Genetics (NIH, Bethesda, USA).

2002-2011 Junior research scientist (1st class)

        Biochemical Genetics and Cytogenetics Laboratory (2002-2009),  

        UMR 1313 Animal Genetics and Integrative Biology Laboratory (since 2010) (INRA, Jouy-en-Josas).

Since 2012 Senior research scientist (2nd class)

        UMR 1313 Animal Genetics and Integrative Biology Laboratory (INRAE, Jouy-en-Josas).

Team leadership Functions

2003-2008 Leader of the "gene to phenotype" team,

        Biochemical Genetics and Cytogenetics Laboratory (INRA, Jouy-en-Josas).

2009-2013 Leader of the "Cell differentiation and specialization team" (DISC),

       UMR 1313 Animal Genetics and Integrative Biology Laboratory (INRA, Jouy-en-Josas).

Since 2014 Leader of the « Mammary Gland Functional Genomics and Physiology Team» (GFP-GM),

       UMR 1313 Animal Genetics and Integrative Biology Laboratory (INRAE, Jouy-en-Josas). (https://www.jouy.inra.fr/gabi/les-Recherches/Equipes-de-recherche/GFP-GM)

Since 2019 Leader of the "Mammary Gland and Lactation Team" (GaLac),

       UMR 1313 Animal Genetics and Integrative Biology Laboratory (INRAE, Jouy-en-Josas).(https://www6.jouy.inrae.fr/gabi/Les-Recherches/Equipes-de-recherche/GaLac)

Contribution to research collectives

2008-2012   Elected member of the Scientific Steering Committee of the INRA Jouy-en-Josas research center.

Since 2016 Appointed member of the INRA Jouy-en-Josas research center council.

Since 2011 Elected member of the INRA Animal Genetics Division Scientific steering committee.

Since 2015 Member of the Plant and Animal Genetics Specialized Scientific Commission.

2011-2015 Leader of the microARN Club, INRA CEnter, Jouy-en-Josas. (http://www.jouy.inra.fr/gabi/les-Recherches/Le-club-microARN).

Recent Publications

ORCID : 0000-0002-0588-5333

2017

Leroux C., Milenkovic D., Mobuchon L., Le Guillou S., Faulconnier Y., German B. and Le Provost F. Nutritional Regulation of Mammary miRNome: Implications for Human Studies. In: Patel V., Preedy V. (eds) Handbook of Nutrition, Diet, and Epigenetics.2017. 1-17. Springer, Cham

Mobuchon L, Le Guillou S, Marthey S, Laubier J, Laloë D, Bes S, Le Provost F, Leroux C (2017) Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland. PLoS One. 12:e0185511.

2016

Chadi S., Polyte J., Lefevre L., Castille J., Ehanno A., Laubier J., Jaffrézic F., Le Provost F (2016) Phenotypic and molecular alterations in the mammary tissue of R-spondin1 knock-out mice during pregnancy. PLoS One 9:e0162566.

2015

Laubier J, Castille J, Le Guillou S, Le Provost F (2015) No effect of an elevated miR-30b level in mouse milk on its level in pup tissues. RNA Biology 12:26-9. doi: 10.1080/15476286.2015.1017212.

Mobuchon L, Marthey S, Le Guillou S, Laloë D, Le Provost F, Leroux C (2015a) Food Deprivation Affects the miRNome in the Lactating Goat Mammary Gland. PLoS One 16:e0140111.

Mobuchon L, Marthey S, Boussaha M, Le Guillou S, Leroux C, Le Provost F (2015b) Annotation of the goat genome using next generation sequencing of microRNA expressed by the lactating mammary gland: comparison of three approaches. BMC Genomics. 16:285.

2014

Baco M, Chu CY, Bouet S, Rogel-Gaillard C, Bourneuf E, Le Provost F, Chu CY, Vincent-Naulleau S (2014) Analysis of melanoma-related microRNAs expression during the spontaneous regression of cutaneous melanomas in MeLiM pigs. Pigment Cell Melanoma Res. 27:668-70.

Le Guillou S, Marthey S, Laloë D, Laubier J, Mobuchon L, Leroux C, Le Provost F (2014) Characterisation and comparison of lactating mouse and bovine mammary gland miRNomes. PLoS One 9:e91938.

2013

Doridot L, Passet B, Méhats C, Rigourd V, Barbaux S, Ducat A, Mondon F, Vilotte M, Castille J, Breuiller-Fouché M, Daniel N, Le Provost F, Bauchet AL, Baudrie V, Hertig A, Buffat C, Simeoni U, Germain G, Vilotte JL, Vaiman D (2013) Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment. Hypertension. 61:662-8.

Leroux C, Bernard L, Dessauge F, Le Provost F, Martin P (2013) The function of lactation : regulation of biosynthesis of milk components. INRA Prod Anim. 26:117-128.

Current main scientific projects

v  ANR ReidSOCS 2016-2020: Robustness, efficiency, inflammation and diseases under the control of SOCS-2.

v  CASDAR-RT BioMarq’Lait 2018-2021: Identification dans le lait de biomarqueurs pour le monitoring du statut nutritionnel de la vache laitière.

v  Métaprogramme GISA: LongHealth 2017-2019 Integrated management of ruminant health for a sustainable dairy production.

v  Apis-Gene NutrimiRMa 2013-2015: Nutritional regulation of mammary gland microRNA in ruminants and their impact on the biosynthesis of milk components.

v  Apis-Gene miRQTLait 2017-2019: Search for associations between microRNA, genetic variants and dairy QTL.