Know more

About cookies

What is a "cookie"?

A "cookie" is a piece of information, usually small and identified by a name, which may be sent to your browser by a website you are visiting. Your web browser will store it for a period of time, and send it back to the web server each time you log on again.

Different types of cookies are placed on the sites:

  • Cookies strictly necessary for the proper functioning of the site
  • Cookies deposited by third party sites to improve the interactivity of the site, to collect statistics

Learn more about cookies and how they work

The different types of cookies used on this site

Cookies strictly necessary for the site to function

These cookies allow the main services of the site to function optimally. You can technically block them using your browser settings but your experience on the site may be degraded.

Furthermore, you have the possibility of opposing the use of audience measurement tracers strictly necessary for the functioning and current administration of the website in the cookie management window accessible via the link located in the footer of the site.

Technical cookies

Name of the cookie

Purpose

Shelf life

CAS and PHP session cookies

Login credentials, session security

Session

Tarteaucitron

Saving your cookie consent choices

12 months

Audience measurement cookies (AT Internet)

Name of the cookie

Purpose

Shelf life

atid

Trace the visitor's route in order to establish visit statistics.

13 months

atuserid

Store the anonymous ID of the visitor who starts the first time he visits the site

13 months

atidvisitor

Identify the numbers (unique identifiers of a site) seen by the visitor and store the visitor's identifiers.

13 months

About the AT Internet audience measurement tool :

AT Internet's audience measurement tool Analytics is deployed on this site in order to obtain information on visitors' navigation and to improve its use.

The French data protection authority (CNIL) has granted an exemption to AT Internet's Web Analytics cookie. This tool is thus exempt from the collection of the Internet user's consent with regard to the deposit of analytics cookies. However, you can refuse the deposit of these cookies via the cookie management panel.

Good to know:

  • The data collected are not cross-checked with other processing operations
  • The deposited cookie is only used to produce anonymous statistics
  • The cookie does not allow the user's navigation on other sites to be tracked.

Third party cookies to improve the interactivity of the site

This site relies on certain services provided by third parties which allow :

  • to offer interactive content;
  • improve usability and facilitate the sharing of content on social networks;
  • view videos and animated presentations directly on our website;
  • protect form entries from robots;
  • monitor the performance of the site.

These third parties will collect and use your browsing data for their own purposes.

How to accept or reject cookies

When you start browsing an eZpublish site, the appearance of the "cookies" banner allows you to accept or refuse all the cookies we use. This banner will be displayed as long as you have not made a choice, even if you are browsing on another page of the site.

You can change your choices at any time by clicking on the "Cookie Management" link.

You can manage these cookies in your browser. Here are the procedures to follow: Firefox; Chrome; Explorer; Safari; Opera

For more information about the cookies we use, you can contact INRAE's Data Protection Officer by email at cil-dpo@inrae.fr or by post at :

INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal AgroParisTech Université Paris-Saclay SAPS - Sciences Animales Paris-Saclay

INRA GABI Unit

GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

Fabienne LE PROVOST, Senior Research Scientist

Leader of the "Mammary Gland and Lactation" team (GaLac)

Fabienne Le Provost
© INRAE
My research projects are aimed at better understanding the environmental and genetic factors that have an influence on the mother-offspring continuum via milk and to decode the associated molecular mechanisms. To do this, I study, on the one hand, the mammary gland whose establishment plays a key role in milk production, and on the other hand, the composition of milk, the central element of this continuum.

 

INRAE UMR 1313 Génétique Animale et Biologie Intégrative
Domaine de Vilvert, Bat 440, 78352 Jouy en Josas
Tel : +33 (0) 1 34 65 25 69
Email : fabienne.le-provost(at)inra.fr
ORCID : 0000-0002-0588-5333

Research Team: leader of the Mammary Gland and Lactation Team (GaLac)

Diplômes

  • Nov 2010  HDR (accreditation for directing research). Université Versailles-Saint Quentin.
  • Mai 2004   Animal experimentation certification Level I. Ecole Nationale Vétérinaire, Maisons-Alfort.
  • 1991-1995 PhD in Developmental molecular and cellular biology. Université Paris XI, Orsay.

Career at INRAE

1995 Junior research scientist (2nd class)

        Biochemical Genetics and Cytogenetics Laboratory (INRA, Jouy-en-Josas).

2000-2001 Long-term mission

        Laboratory Physiology and Genetics (NIH, Bethesda, USA).

2002-2011 Junior research scientist (1st class)

        Biochemical Genetics and Cytogenetics Laboratory (2002-2009),  

        UMR 1313 Animal Genetics and Integrative Biology Laboratory (since 2010) (INRA, Jouy-en-Josas).

Since 2012 Senior research scientist (2nd class)

        UMR 1313 Animal Genetics and Integrative Biology Laboratory (INRAE, Jouy-en-Josas).

Team leadership Functions

2003-2008 Leader of the "gene to phenotype" team,

        Biochemical Genetics and Cytogenetics Laboratory (INRA, Jouy-en-Josas).

2009-2013 Leader of the "Cell differentiation and specialization team" (DISC),

       UMR 1313 Animal Genetics and Integrative Biology Laboratory (INRA, Jouy-en-Josas).

Since 2014 Leader of the « Mammary Gland Functional Genomics and Physiology Team» (GFP-GM),

       UMR 1313 Animal Genetics and Integrative Biology Laboratory (INRAE, Jouy-en-Josas). (https://www.jouy.inra.fr/gabi/les-Recherches/Equipes-de-recherche/GFP-GM)

Since 2019 Leader of the "Mammary Gland and Lactation Team" (GaLac),

       UMR 1313 Animal Genetics and Integrative Biology Laboratory (INRAE, Jouy-en-Josas).(https://www6.jouy.inrae.fr/gabi/Les-Recherches/Equipes-de-recherche/GaLac)

Contribution to research collectives

2008-2012   Elected member of the Scientific Steering Committee of the INRA Jouy-en-Josas research center.

Since 2016 Appointed member of the INRA Jouy-en-Josas research center council.

Since 2011 Elected member of the INRA Animal Genetics Division Scientific steering committee.

Since 2015 Member of the Plant and Animal Genetics Specialized Scientific Commission.

2011-2015 Leader of the microARN Club, INRA CEnter, Jouy-en-Josas. (http://www.jouy.inra.fr/gabi/les-Recherches/Le-club-microARN).

Recent Publications

ORCID : 0000-0002-0588-5333

2017

Leroux C., Milenkovic D., Mobuchon L., Le Guillou S., Faulconnier Y., German B. and Le Provost F. Nutritional Regulation of Mammary miRNome: Implications for Human Studies. In: Patel V., Preedy V. (eds) Handbook of Nutrition, Diet, and Epigenetics.2017. 1-17. Springer, Cham

Mobuchon L, Le Guillou S, Marthey S, Laubier J, Laloë D, Bes S, Le Provost F, Leroux C (2017) Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland. PLoS One. 12:e0185511.

2016

Chadi S., Polyte J., Lefevre L., Castille J., Ehanno A., Laubier J., Jaffrézic F., Le Provost F (2016) Phenotypic and molecular alterations in the mammary tissue of R-spondin1 knock-out mice during pregnancy. PLoS One 9:e0162566.

2015

Laubier J, Castille J, Le Guillou S, Le Provost F (2015) No effect of an elevated miR-30b level in mouse milk on its level in pup tissues. RNA Biology 12:26-9. doi: 10.1080/15476286.2015.1017212.

Mobuchon L, Marthey S, Le Guillou S, Laloë D, Le Provost F, Leroux C (2015a) Food Deprivation Affects the miRNome in the Lactating Goat Mammary Gland. PLoS One 16:e0140111.

Mobuchon L, Marthey S, Boussaha M, Le Guillou S, Leroux C, Le Provost F (2015b) Annotation of the goat genome using next generation sequencing of microRNA expressed by the lactating mammary gland: comparison of three approaches. BMC Genomics. 16:285.

2014

Baco M, Chu CY, Bouet S, Rogel-Gaillard C, Bourneuf E, Le Provost F, Chu CY, Vincent-Naulleau S (2014) Analysis of melanoma-related microRNAs expression during the spontaneous regression of cutaneous melanomas in MeLiM pigs. Pigment Cell Melanoma Res. 27:668-70.

Le Guillou S, Marthey S, Laloë D, Laubier J, Mobuchon L, Leroux C, Le Provost F (2014) Characterisation and comparison of lactating mouse and bovine mammary gland miRNomes. PLoS One 9:e91938.

2013

Doridot L, Passet B, Méhats C, Rigourd V, Barbaux S, Ducat A, Mondon F, Vilotte M, Castille J, Breuiller-Fouché M, Daniel N, Le Provost F, Bauchet AL, Baudrie V, Hertig A, Buffat C, Simeoni U, Germain G, Vilotte JL, Vaiman D (2013) Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment. Hypertension. 61:662-8.

Leroux C, Bernard L, Dessauge F, Le Provost F, Martin P (2013) The function of lactation : regulation of biosynthesis of milk components. INRA Prod Anim. 26:117-128.

Current main scientific projects

v  ANR ReidSOCS 2016-2020: Robustness, efficiency, inflammation and diseases under the control of SOCS-2.

v  CASDAR-RT BioMarq’Lait 2018-2021: Identification dans le lait de biomarqueurs pour le monitoring du statut nutritionnel de la vache laitière.

v  Métaprogramme GISA: LongHealth 2017-2019 Integrated management of ruminant health for a sustainable dairy production.

v  Apis-Gene NutrimiRMa 2013-2015: Nutritional regulation of mammary gland microRNA in ruminants and their impact on the biosynthesis of milk components.

v  Apis-Gene miRQTLait 2017-2019: Search for associations between microRNA, genetic variants and dairy QTL.