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Lines of research

• Methanization of ligno-cellulosic waste and biowaste, inhibition mitigation and process optimisation
• Molecular ecology approaches (omics, isotope labelling) to study complex microbial communities
• Non-targeted metabolomics to decipher biodegradation pathways
• Statistical analysis of data, omics data integration, time-course modelling

Ongoing and past projects

• STABILICS - ANR project (2019-2023) | Coupling statistics and multi-omics to gain new insights in the determinants of anaerobic microbial bioprocess stability
• DIGESTOMIC - ANR project (2016-2020) | New operational strategies to overcome technical barriers in anaerobic digestion and extend its fields of application by using meta-omic approaches
• FASIC PHC project (2017-2018) | Novel statistical methods to improve waste degradation: merging advanced biotechnologies with forefront analytical tools, identification of biomarkers by integrating multiple-omics datasets 
• METHARESIST - EC2CO project (2015-2016) | Omics approaches to identify resistance strategies of anaerobic digesters to micropollutants : example of phenol

Professional experiences

• 2019 | Habilitation thesis (Diplôme d’Habilitation à diriger des recherches) in biology, Université Paris-Saclay, France
• March - May 2019 | Visitor scientist to Dr Lê Cao, Melbourne Integrative Genomics, University of Melbourne, Melbourne, Australia
• August - December 2017 | Visitor scientist to Dr Lê Cao, Melbourne Integrative Genomics, University of Melbourne, Melbourne, Australia
• February - May 2017 | Visitor scientist to Dr Déjean, Institut de Mathématiques de Toulouse, Université Paul Sabatier, Toulouse, France
• 2012 | PhD, environmental sciences, AgroParisTech, France

Supervision

PhD students

• Laëtitia Cardona (2017-2020) | "Advancing environmental biotechnologies through molecular ecology approaches: from description to management" 
• Simon Poirier (2013-2016) | "Anaerobic digestion inhibitions: ecological dynamics, microbial indicators and resistance strategies. Examples of phenol and ammonia nitrogen"

Postdoc

• Francesc Puig-Castellví (2018-2020) 

Other

• Supervision of 17 master students or foreign PhD students during short stays in the lab

Teaching

Master Degree ECOSEM Ecotechnologies for Sustainability and Environment Management, Ecole polytechnique

Selected publications

• Assessment of substrate biodegradability improvement in anaerobic Co-digestion using a chemometrics-based metabolomic approach. Puig-Castellví, F., Cardona, L., Jouan-Rimbaud Bouveresse, D., Cordella, C.B.Y., Mazéas, L., Rutledge, D.N., Chapleur, O. (2020). Chemosphere. 254:126812. DOI: 10.1016/j.chemosphere.2020.126812
• Assessment of the microbial interplay during anaerobic co-digestion of wastewater sludge using common components analysis. Puig-Castellví, F., Cardona, L., Jouan-Rimbaud Bouveresse, D., Cordella, C.B.Y., Mazéas, L., Rutledge, D.N., Chapleur, O. (2020). PLOS ONE, 15:e0232324. DOI: 10.1371/journal.pone.0232324
• Ecological consequences of abrupt temperature changes in anaerobic digesters. Madigou, C., Lê Cao, K.-A., Bureau, C., Mazéas, L., Déjean, S., Chapleur, O. (2019). Chemical Engineering Journal, 361:266-277. DOI: 10.1016/j.cej.2018.12.003
• A generic multivariate framework for the integration of microbiome longitudinal studies with other data types. Bodein, A.⁺, Chapleur, O.⁺, Droit, A., Lê Cao, K. (2019). Frontiers in Genetics. DOI: 10.3389/fgene.2019.00963
• Anaerobic digestion of biowaste under extreme ammonia concentration: Identification of key microbial phylotypes. Poirier, S., Desmond-Le Quéméner, E., Madigou, C., Bouchez, T., Chapleur, O. (2016). Bioresource Technology, 207:92-101. DOI: 10.1016/j.biortech.2016.01.124  
• Asymmetrical response of anaerobic digestion microbiota to temperature changes. Chapleur, O., Mazéas, L., Godon, J.J., Bouchez, T. (2016). Applied Microbiology and Biotechnology, 100:1445-1457. DOI: 10.1007/s00253-015-7046-7
• Co-inoculating ruminal content neither provides active hydrolytic microbes nor improves methanization of ¹³C-cellulose in batch digesters. Chapleur, O., Bize, A., Serain, T., Mazéas, L., Bouchez, T. (2014). FEMS Microbiology Ecology, 87: 616-629. DOI: 10.1111/1574-6941.12249