Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free: https://www.ghostery.com/fr/products/

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site: http://www.youronlinechoices.com/fr/controler-ses-cookies/, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Realytics
Google Analytics
Spoteffects
Optimizely

Targeted advertising cookies

DoubleClick
Mediarithmics

The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at cil-dpo@inra.fr or by post at:

INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal

Home

Unité de Virologie et Immunologie Moléculaires

Coronavirus

Coronaviruses are viruses generally responsible for infections of the epithelia of the digestive and respiratory systems in humans, but also in animals (mammals and birds). The appearance of their viral particles with a crown of 20 nm high projections anchored in the viral membrane is characteristic of this family.

These projections called spikes are exclusively composed of protein S assembled into a homotrimer. The essential function of S is to recognize and bind to a specific receptor on the cell surface, this interaction being the first step in the entry of the virus into the target cell.

Our work mainly focuses on SARS-CoV-2 and to a lesser extent on coronaviruses of veterinary interest.

Global

Our scientific objectives are:

We were able to show on the hamster model that infection with SARS-CoV-2 lead to massive desquamation of the olfactory epithelium ensuring the first step in the detection of odors in the nasal cavity, which explains the symptom of anosmia often seen in patients with COVID-19. We seek to understand the cellular origins of this phenomenon in order to develop therapeutic approaches but also to extend our results more generally to the relationships between respiratory viruses and the nasal cavity.

We have selected artificial proteins that bind with high affinity to the SARS-CoV-2 spike. Some of them are able to neutralize the virus in cell culture and are shown to have therapeutic properties of interest. This project is extended by the development of original strategies to increase the bioavailability of these antivirals in the nasal cavity. We anticipate that they will thus be able to effectively block horizontal transmission of the virus.

Not all cell receptors for animal coronaviruses are identified. More particularly, the nature of the receptor for the avian infectious bronchitis virus as well as for the porcine epidemic diarrhoea virus, two coronaviruses having a strong economic impact in the avian and pork production sectors, have not been identified. We are developing experimental strategies to characterize them.