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Unité de Virologie et Immunologie Moléculaires




Screening antivirals with a mCherry-expressing recombinant bovine respiratory syncytial virus: a proof of concept using cyclopamine. Fix J, Descamps D, Galloux M, Ferret C, Bouguyon E, Zohari S, Näslund K, Hägglund S, Altmeyer R, Valarcher JF, Riffault S, Eléouët JF.Vet Res. 2023 Apr 17;54(1):36. doi: 10.1186/s13567-023-01165-x.

Biochemistry of the Respiratory Syncytial Virus L Protein Embedding RNA Polymerase and Capping Activities.Sutto-Ortiz P, Eléouët JF, Ferron F, Decroly E.Viruses. 2023 Jan 25;15(2):341. doi: 10.3390/v15020341.PMID: 36851554

Level of maternal antibodies against respiratory syncytial virus (RSV) nucleoprotein at birth and risk of RSV very severe lower respiratory tract infection. Receveur M, Ottmann M, Reynes JM, Eleouet JF, Galloux M, Receveur A, Ploin D, Fiorini S, Rivat N, Valette M, Lina B, Casalegno JS.Influenza Other Respir Viruses. 2023 Jan;17(1):e13025. doi: 10.1111/irv.13025. Epub 2022 Oct 17.PMID: 36251946


Investigation of the Fuzzy Complex between RSV Nucleoprotein and Phosphoprotein to Optimize an Inhibition Assay by Fluorescence Polarization. Khodjoyan S, Morissette D, Hontonnou F, Checa Ruano L, Richard CA, Sperandio O, Eléouët JF, Galloux M, Durand P, Deville-Foillard S, Sizun C.Int J Mol Sci. 2022 Dec 29;24(1):569. doi: 10.3390/ijms24010569.PMID: 36614009 

Level of maternal antibodies against respiratory syncytial virus (RSV) nucleoprotein at birth and risk of RSV very severe lower respiratory tract infection. Receveur M, Ottmann M, Reynes JM, Eleouet JF, Galloux M, Receveur A, Ploin D, Fiorini S, Rivat N, Valette M, Lina B, Casalegno JS.Influenza Other Respir Viruses. 2022 Oct 17. doi: 10.1111/irv.13025. Online ahead of print.PMID: 36251946

Longitudinal study of the immune response and memory following natural bovine respiratory syncytial virus infections in cattle of different age. Hägglund S, Näslund K, Svensson A, Lefverman C, Enül H, Pascal L, Siltenius J, Holzhauer M, Delabouglise A, Österberg J, Alvåsen K, Olsson U, Eléouët JF, Riffault S, Taylor G, Rodriguez MJ, Garcia Duran M, Valarcher JF.PLoS One. 2022 Sep 16;17(9):e0274332. doi: 10.1371/journal.pone.0274332. eCollection 2022.PMID: 36112582

Importance of RNA length for in vitro encapsidation by the nucleoprotein of human respiratory syncytial virus. Gonnin L, Richard CA, Gutsche I, Chevret D, Troussier J, Vasseur JJ, Debart F, Eléouët JF, Galloux M.J Biol Chem. 2022 Sep;298(9):102337. doi: 10.1016/j.jbc.2022.102337. Epub 2022 Aug 3.PMID: 35931116 

Respiratory Syncytial Virus NS1 Protein Targets the Transactivator Binding Domain of MED25. Dong J, Basse V, Bierre M, Peres de Oliveira A, Vidalain PO, Sibille P, Tangy F, Galloux M, Eleouet JF, Sizun C, Bajorek M.J Mol Biol. 2022 Oct 15;434(19):167763. doi: 10.1016/j.jmb.2022.167763. Epub 2022 Jul 28.PMID: 35907573

RIG-I activation inhibits human respiratory syncytial virus replication in mammalian cells and in mouse and ferret models of infection. Schwab LSU, Farrukee R, Eléouët JF, Rameix-Welti MA, Londrigan SL, Brooks AG, Hurt AC, Coch C, Zillinger T, Hartmann G, Reading PC.J Infect Dis. 2022 Jul 21:jiac295. doi: 10.1093/infdis/jiac295. Online ahead of print.PMID: 35861054

Characterization of the Interaction Domains between the Phosphoprotein and the Nucleoprotein of Human Metapneumovirus. Decool H, Bardiaux B, Checa Ruano L, Sperandio O, Fix J, Gutsche I, Richard CA, Bajorek M, Eléouët JF, Galloux M.J Virol. 2022 Jan 26;96(2):e0090921. doi: 10.1128/JVI.00909-21. Epub 2021 Nov 3.PMID: 34730389 Free PMC article.


Interactions between the Nucleoprotein and the Phosphoprotein of Pneumoviruses: Structural Insight for Rational Design of Antivirals. Decool H, Gonnin L, Gutsche I, Sizun C, Eléouët JF, Galloux M.Viruses. 2021 Dec 6;13(12):2449. doi: 10.3390/v13122449.PMID: 34960719 Free PMC article. Review.

Avian Cell Line DuckCelt®-T17 Is an Efficient Production System for Live-Attenuated Human Metapneumovirus Vaccine Candidate Metavac®. Chupin C, Pizzorno A, Traversier A, Brun P, Ogonczyk-Makowska D, Padey B, Milesi C, Dulière V, Laurent E, Julien T, Galloux M, Lina B, Eléouët JF, Moreau K, Hamelin ME, Terrier O, Boivin G, Dubois J, Rosa-Calatrava M.Vaccines (Basel). 2021 Oct 16;9(10):1190. doi: 10.3390/vaccines9101190.PMID: 34696298 Free PMC article.

A Structural and Dynamic Analysis of the Partially Disordered Polymerase-Binding Domain in RSV Phosphoprotein. Cardone C, Caseau CM, Bardiaux B, Thureaux A, Galloux M, Bajorek M, Eléouët JF, Litaudon M, Bontems F, Sizun C.Biomolecules. 2021 Aug 17;11(8):1225. doi: 10.3390/biom11081225.PMID: 34439894 Free PMC article.

Depletion of TAX1BP1 Amplifies Innate Immune Responses during Respiratory Syncytial Virus Infection. Descamps D, Peres de Oliveira A, Gonnin L, Madrières S, Fix J, Drajac C, Marquant Q, Bouguyon E, Pietralunga V, Iha H, Morais Ventura A, Tangy F, Vidalain PO, Eléouët JF, Galloux M.J Virol. 2021 Oct 27;95(22):e0091221. doi: 10.1128/JVI.00912-21. Epub 2021 Aug 25.PMID: 34431698

A condensate-hardening drug blocks RSV replication in vivo. Risso-Ballester J, Galloux M, Cao J, Le Goffic R, Hontonnou F, Jobart-Malfait A, Desquesnes A, Sake SM, Haid S, Du M, Zhang X, Zhang H, Wang Z, Rincheval V, Zhang Y, Pietschmann T, Eléouët JF, Rameix-Welti MA, Altmeyer R.Nature. 2021 Jul;595(7868):596-599. doi: 10.1038/s41586-021-03703-z. Epub 2021 Jul 7.PMID: 34234347

Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection. Brügger M, Démoulins T, Barut GT, Zumkehr B, Oliveira Esteves BI, Mehinagic K, Haas Q, Schögler A, Rameix-Welti MA, Eléouët JF, Moehrlen U, Marti TM, Schmid RA, Summerfield A, Posthaus H, Ruggli N, Hall SRR, Alves MP.PLoS Pathog. 2021 Jul 28;17(7):e1009789. doi: 10.1371/journal.ppat.1009789. eCollection 2021 Jul.PMID: 34320038 Free PMC article.

Hyper-Enriched Anti-RSV Immunoglobulins Nasally Administered: A Promising Approach for Respiratory Syncytial Virus Prophylaxis. Jacque E, Chottin C, Laubreton D, Nogre M, Ferret C, de Marcos S, Baptista L, Drajac C, Mondon P, De Romeuf C, Rameix-Welti MA, Eléouët JF, Chtourou S, Riffault S, Perret G, Descamps D.Front Immunol. 2021 Jun 7;12:683902. doi: 10.3389/fimmu.2021.683902. eCollection 2021.PMID: 34163482 Free PMC article.

The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2'-O-methylation.Sutto-Ortiz P, Tcherniuk S, Ysebaert N, Abeywickrema P, Noël M, Decombe A, Debart F, Vasseur JJ, Canard B, Roymans D, Rigaux P, Eléouët JF, Decroly E.PLoS Pathog. 2021 May 6;17(5):e1009562. doi: 10.1371/journal.ppat.1009562. eCollection 2021 May.PMID: 33956914 Free article.

New Look at RSV Infection: Tissue Clearing and 3D Imaging of the Entire Mouse Lung at Cellular Resolution.Frétaud M, Descamps D, Laubreton D, Rameix-Welti MA, Eléouët JF, Larcher T, Galloux M, Langevin C.Viruses. 2021 Jan 28;13(2):201. doi: 10.3390/v13020201.PMID: 33525646 Free PMC article.

Tetramerization of Phosphoprotein is Essential for Respiratory Syncytial Virus Budding while its N Terminal Region Mediates Direct Interactions with the Matrix Protein.Bajorek M, Galloux M, Richard CA, Szekely O, Rosenzweig R, Sizun C, Eleouet JF.J Virol. 2021 Jan 6;95(7):e02217-20. doi: 10.1128/JVI.02217-20. Online ahead of print.PMID: 33408180


Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection.Pålsson SA, Dondalska A, Bergenstråhle J, Rolfes C, Björk A, Sedano L, Power UF, Rameix-Welti MA, Lundeberg J, Wahren-Herlenius M, Mastrangelo P, Eleouet JF, Le Goffic R, Galloux M, Spetz AL.Front Immunol. 2020 Dec 8;11:580547. doi: 10.3389/fimmu.2020.580547. eCollection 2020.PMID: 33363532 Free PMC article.

Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro.Galloux M, Risso-Ballester J, Richard CA, Fix J, Rameix-Welti MA, Eléouët JF.mBio. 2020 Sep 22;11(5):e01202-20. doi: 10.1128/mBio.01202-20.PMID: 32963000 Free PMC article.

Regulatory B Lymphocytes Colonize the Respiratory Tract of Neonatal Mice and Modulate Immune Responses of Alveolar Macrophages to RSV Infection in IL-10-Dependant Manner.Laubreton D, Drajac C, Eléouët JF, Rameix-Welti MA, Lo-Man R, Riffault S, Descamps D.Viruses. 2020 Jul 29;12(8):822. doi: 10.3390/v12080822.PMID: 32751234 Free PMC article.

Targeting the Respiratory Syncytial Virus N0-P Complex with Constrained α-Helical Peptides in Cells and Mice.Galloux M, Gsponer N, Gaillard V, Fenner B, Larcher T, Vilotte M, Rivière J, Richard CA, Eléouët JF, Le Goffic R, Mettier J, Nyanguile O.Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00717-20. doi: 10.1128/AAC.00717-20. Print 2020 Sep 21.PMID: 32660994 Free PMC article.

Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like Restrict Replication of Respiratory Syncytial Virus.Busse DC, Habgood-Coote D, Clare S, Brandt C, Bassano I, Kaforou M, Herberg J, Levin M, Eléouët JF, Kellam P, Tregoning JS.J Virol. 2020 Aug 31;94(18):e00297-20. doi: 10.1128/JVI.00297-20. Print 2020 Aug 31.PMID: 32611756 Free PMC article.

[Molecular mechanisms of respiratory syncytial virus replication: a guide for the development of antivirals].Eléouët JF.Virologie (Montrouge). 2020 Apr 1;24(2):99-112. doi: 10.1684/vir.2020.0834.PMID: 32540831 French.

A Single Shot Pre-fusion-Stabilized Bovine RSV F Vaccine is Safe and Effective in Newborn Calves with Maternally Derived Antibodies.Riffault S, Hägglund S, Guzman E, Näslund K, Jouneau L, Dubuquoy C, Pietralunga V, Laubreton D, Boulesteix O, Gauthier D, Remot A, Boukaridi A, Falk A, Shevchenko G, Lind SB, Vargmar K, Zhang B, Kwong PD, Rodriguez MJ, Duran MG, Schwartz-Cornil I, Eléouët JF, Taylor G, Valarcher JF.Vaccines (Basel). 2020 May 18;8(2):231. doi: 10.3390/vaccines8020231.PMID: 32443437 Free PMC article.

De novo protein design enables the precise induction of RSV-neutralizing antibodies.Sesterhenn F, Yang C, Bonet J, Cramer JT, Wen X, Wang Y, Chiang CI, Abriata LA, Kucharska I, Castoro G, Vollers SS, Galloux M, Dheilly E, Rosset S, Corthésy P, Georgeon S, Villard M, Richard CA, Descamps D, Delgado T, Oricchio E, Rameix-Welti MA, Más V, Ervin S, Eléouët JF, Riffault S, Bates JT, Julien JP, Li Y, Jardetzky T, Krey T, Correia BE.Science. 2020 May 15;368(6492):eaay5051. doi: 10.1126/science.aay5051.PMID: 32409444 Free PMC article.

Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry.Blockus S, Sake SM, Wetzke M, Grethe C, Graalmann T, Pils M, Le Goffic R, Galloux M, Prochnow H, Rox K, Hüttel S, Rupcic Z, Wiegmann B, Dijkman R, Rameix-Welti MA, Eléouët JF, Duprex WP, Thiel V, Hansen G, Brönstrup M, Haid S, Pietschmann T.Antiviral Res. 2020 May;177:104774. doi: 10.1016/j.antiviral.2020.104774. Epub 2020 Mar 18.PMID: 32197980 Free article.

Respiratory syncytial virus tropism for olfactory sensory neurons in mice.Bryche B, Frétaud M, Saint-Albin Deliot A, Galloux M, Sedano L, Langevin C, Descamps D, Rameix-Welti MA, Eléouët JF, Le Goffic R, Meunier N.J Neurochem. 2020 Sep;155(2):137-153. doi: 10.1111/jnc.14936. Epub 2020 Jan 8.PMID: 31811775

A small fragmented P protein of respiratory syncytial virus inhibits virus infection by targeting P protein.Hara K, Yaita K, Khamrin P, Kumthip K, Kashiwagi T, Eléouët JF, Rameix-Welti MA, Watanabe H.J Gen Virol. 2020 Jan;101(1):21-32. doi: 10.1099/jgv.0.001350.PMID: 31702536


The Interactome analysis of the Respiratory Syncytial Virus protein M2-1 suggests a new role in viral mRNA metabolism post-transcription.Bouillier C, Cosentino G, Léger T, Rincheval V, Richard CA, Desquesnes A, Sitterlin D, Blouquit-Laye S, Eléouët JF, Gault E, Rameix-Welti MA.Sci Rep. 2019 Oct 24;9(1):15258. doi: 10.1038/s41598-019-51746-0.PMID: 31649314 Free PMC article.

Structure of the Respiratory Syncytial Virus Polymerase Complex.Gilman MSA, Liu C, Fung A, Behera I, Jordan P, Rigaux P, Ysebaert N, Tcherniuk S, Sourimant J, Eléouët JF, Sutto-Ortiz P, Decroly E, Roymans D, Jin Z, McLellan JS.Cell. 2019 Sep 19;179(1):193-204.e14. doi: 10.1016/j.cell.2019.08.014. Epub 2019 Sep 5.PMID: 31495574 Free PMC article.

High-throughput screening of active compounds against human respiratory syncytial virus.Fu YH, Xu ZX, Jiang N, Zheng YP, Rameix-Welti MA, Jiao YY, Peng XL, Wang Y, Eleouet JF, Cen S, He JS.Virology. 2019 Sep;535:171-178. doi: 10.1016/j.virol.2019.07.002. Epub 2019 Jul 3.PMID: 31306912 Free article.

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses.Bouillier C, Rincheval V, Sitterlin D, Blouquit-Laye S, Desquesnes A, Eléouët JF, Gault E, Rameix-Welti MA.J Vis Exp. 2019 Apr 4;(146). doi: 10.3791/59218.PMID: 31009004

Evaluation of the Antiviral Activity of Sephin1 Treatment and Its Consequences on eIF2α Phosphorylation in Response to Viral Infections.Fusade-Boyer M, Dupré G, Bessière P, Khiar S, Quentin-Froignant C, Beck C, Lecollinet S, Rameix-Welti MA, Eléouët JF, Tangy F, Lajoie B, Bertagnoli S, Vidalain PO, Gallardo F, Volmer R.Front Immunol. 2019 Feb 12;10:134. doi: 10.3389/fimmu.2019.00134. eCollection 2019.PMID: 30809223 Free PMC article.

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen.Sesterhenn F, Galloux M, Vollers SS, Csepregi L, Yang C, Descamps D, Bonet J, Friedensohn S, Gainza P, Corthésy P, Chen M, Rosset S, Rameix-Welti MA, Éléouët JF, Reddy ST, Graham BS, Riffault S, Correia BE.PLoS Biol. 2019 Feb 21;17(2):e3000164. doi: 10.1371/journal.pbio.3000164. eCollection 2019 Feb.PMID: 30789898 Free PMC article.

Biochemical characterization of the respiratory syncytial virus N0-P complex in solution.Esneau C, Raynal B, Roblin P, Brûlé S, Richard CA, Fix J, Eléouët JF, Galloux M.J Biol Chem. 2019 Mar 8;294(10):3647-3660. doi: 10.1074/jbc.RA118.006453. Epub 2019 Jan 9.PMID: 30626736 Free PMC article.

Does Intrinsic Disorder in Proteins Favor Their Interaction with Lipids?Deryusheva E, Nemashkalova E, Galloux M, Richard CA, Eléouët JF, Kovacs D, Van Belle K, Tompa P, Uversky V, Permyakov S.Proteomics. 2019 Mar;19(6):e1800098. doi: 10.1002/pmic.201800098. Epub 2019 Jan 25.PMID: 30592560


First demonstration of the circulation of a pneumovirus in French pigs by detection of anti-swine orthopneumovirus nucleoprotein antibodies.Richard CA, Hervet C, Ménard D, Gutsche I, Normand V, Renois F, Meurens F, Eléouët JF.Vet Res. 2018 Dec 5;49(1):118. doi: 10.1186/s13567-018-0615-x.PMID: 30518406 Free PMC article.

The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex.Selvaraj M, Yegambaram K, Todd EJAA, Richard CA, Dods RL, Pangratiou GM, Trinh CH, Moul SL, Murphy JC, Mankouri J, Éléouët JF, Barr JN, Edwards TA.mBio. 2018 Nov 13;9(6):e01554-18. doi: 10.1128/mBio.01554-18.PMID: 30425144 Free PMC article.

RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription.Richard CA, Rincheval V, Lassoued S, Fix J, Cardone C, Esneau C, Nekhai S, Galloux M, Rameix-Welti MA, Sizun C, Eléouët JF.PLoS Pathog. 2018 Feb 28;14(3):e1006920. doi: 10.1371/journal.ppat.1006920. eCollection 2018 Mar.PMID: 29489893 Free PMC article.

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism.Cagno V, Andreozzi P, D'Alicarnasso M, Jacob Silva P, Mueller M, Galloux M, Le Goffic R, Jones ST, Vallino M, Hodek J, Weber J, Sen S, Janeček ER, Bekdemir A, Sanavio B, Martinelli C, Donalisio M, Rameix Welti MA, Eleouet JF, Han Y, Kaiser L, Vukovic L, Tapparel C, Král P, Krol S, Lembo D, Stellacci F.Nat Mater. 2018 Feb;17(2):195-203. doi: 10.1038/nmat5053. Epub 2017 Dec 18.PMID: 29251725 Free article.

Modular cell-based platform for high throughput identification of compounds that inhibit a viral interferon antagonist of choice.Vasou A, Paulus C, Narloch J, Gage ZO, Rameix-Welti MA, Eléouët JF, Nevels M, Randall RE, Adamson CS.Antiviral Res. 2018 Feb;150:79-92. doi: 10.1016/j.antiviral.2017.10.012. Epub 2017 Oct 14.PMID: 29037975 Free PMC article.


Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus.Rincheval V, Lelek M, Gault E, Bouillier C, Sitterlin D, Blouquit-Laye S, Galloux M, Zimmer C, Eleouet JF, Rameix-Welti MA.Nat Commun. 2017 Sep 15;8(1):563. doi: 10.1038/s41467-017-00655-9.PMID: 28916773 Free PMC article.

Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity.Zhivaki D, Lemoine S, Lim A, Morva A, Vidalain PO, Schandene L, Casartelli N, Rameix-Welti MA, Hervé PL, Dériaud E, Beitz B, Ripaux-Lefevre M, Miatello J, Lemercier B, Lorin V, Descamps D, Fix J, Eléouët JF, Riffault S, Schwartz O, Porcheray F, Mascart F, Mouquet H, Zhang X, Tissières P, Lo-Man R.Immunity. 2017 Feb 21;46(2):301-314. doi: 10.1016/j.immuni.2017.01.010.PMID: 28228284 Free PMC article.

A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading.Gaillard V, Galloux M, Garcin D, Eléouët JF, Le Goffic R, Larcher T, Rameix-Welti MA, Boukadiri A, Héritier J, Segura JM, Baechler E, Arrell M, Mottet-Osman G, Nyanguile O.Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02241-16. doi: 10.1128/AAC.02241-16. Print 2017 Apr.PMID: 28137809 Free PMC article.

New Insights into Structural Disorder in Human Respiratory Syncytial Virus Phosphoprotein and Implications for Binding of Protein Partners.Pereira N, Cardone C, Lassoued S, Galloux M, Fix J, Assrir N, Lescop E, Bontems F, Eléouët JF, Sizun C.J Biol Chem. 2017 Feb 10;292(6):2120-2131. doi: 10.1074/jbc.M116.765958. Epub 2016 Dec 28.PMID: 28031463 Free PMC article.


Non-invasive epicutaneous vaccine against Respiratory Syncytial Virus: Preclinical proof of concept.Hervé PL, Descamps D, Deloizy C, Dhelft V, Laubreton D, Bouguyon E, Boukadiri A, Dubuquoy C, Larcher T, Benhamou PH, Eléouët JF, Bertho N, Mondoulet L, Riffault S.J Control Release. 2016 Dec 10;243:146-159. doi: 10.1016/j.jconrel.2016.10.003. Epub 2016 Oct 6.PMID: 27720994 Free article.

RSV N-nanorings fused to palivizumab-targeted neutralizing epitope as a nanoparticle RSV vaccine.Hervé PL, Deloizy C, Descamps D, Rameix-Welti MA, Fix J, McLellan JS, Eléouët JF, Riffault S.Nanomedicine. 2017 Feb;13(2):411-420. doi: 10.1016/j.nano.2016.08.006. Epub 2016 Aug 20.PMID: 27553073 Free PMC article.

Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication.Bailly B, Richard CA, Sharma G, Wang L, Johansen L, Cao J, Pendharkar V, Sharma DC, Galloux M, Wang Y, Cui R, Zou G, Guillon P, von Itzstein M, Eléouët JF, Altmeyer R.Sci Rep. 2016 May 19;6:25806. doi: 10.1038/srep25806.PMID: 27194388 Free PMC article.


A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus.Ouizougun-Oubari M, Pereira N, Tarus B, Galloux M, Lassoued S, Fix J, Tortorici MA, Hoos S, Baron B, England P, Desmaële D, Couvreur P, Bontems F, Rey FA, Eléouët JF, Sizun C, Slama-Schwok A, Duquerroy S.J Virol. 2015 Nov;89(21):11129-43. doi: 10.1128/JVI.01612-15. Epub 2015 Aug 5.PMID: 26246564 Free PMC article.

A bovine respiratory syncytial virus model with high clinical expression in calves with specific passive immunity.Blodörn K, Hägglund S, Gavier-Widen D, Eléouët JF, Riffault S, Pringle J, Taylor G, Valarcher JF.BMC Vet Res. 2015 Mar 25;11:76. doi: 10.1186/s12917-015-0389-6.PMID: 25890239 Free PMC article.

Fine mapping and characterization of the L-polymerase-binding domain of the respiratory syncytial virus phosphoprotein.Sourimant J, Rameix-Welti MA, Gaillard AL, Chevret D, Galloux M, Gault E, Eléouët JF.J Virol. 2015 Apr;89(8):4421-33. doi: 10.1128/JVI.03619-14. Epub 2015 Feb 4.PMID: 25653447 Free PMC article.

Identification and characterization of the binding site of the respiratory syncytial virus phosphoprotein to RNA-free nucleoprotein.Galloux M, Gabiane G, Sourimant J, Richard CA, England P, Moudjou M, Aumont-Nicaise M, Fix J, Rameix-Welti MA, Eléouët JF.J Virol. 2015 Apr;89(7):3484-96. doi: 10.1128/JVI.03666-14. Epub 2015 Jan 7.PMID: 25568210 Free PMC article.

Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-protein stability and RNA synthesis.Munday DC, Wu W, Smith N, Fix J, Noton SL, Galloux M, Touzelet O, Armstrong SD, Dawson JM, Aljabr W, Easton AJ, Rameix-Welti MA, de Oliveira AP, Simabuco FM, Ventura AM, Hughes DJ, Barr JN, Fearns R, Digard P, Eléouët JF, Hiscox JA.J Virol. 2015 Jan 15;89(2):917-30. doi: 10.1128/JVI.01783-14. Epub 2014 Oct 29.PMID: 25355874 Free PMC article.


Visualizing the replication of respiratory syncytial virus in cells and in living mice.Rameix-Welti MA, Le Goffic R, Hervé PL, Sourimant J, Rémot A, Riffault S, Yu Q, Galloux M, Gault E, Eléouët JF.Nat Commun. 2014 Oct 3;5:5104. doi: 10.1038/ncomms6104.PMID: 25277263 Free PMC article.

Vaccine safety and efficacy evaluation of a recombinant bovine respiratory syncytial virus (BRSV) with deletion of the SH gene and subunit vaccines based on recombinant human RSV proteins: N-nanorings, P and M2-1, in calves with maternal antibodies.Blodörn K, Hägglund S, Fix J, Dubuquoy C, Makabi-Panzu B, Thom M, Karlsson P, Roque JL, Karlstam E, Pringle J, Eléouët JF, Riffault S, Taylor G, Valarcher JF.PLoS One. 2014 Jun 19;9(6):e100392. doi: 10.1371/journal.pone.0100392. eCollection 2014.PMID: 24945377 Free PMC article.

Characterization of an experimental vaccine for bovine respiratory syncytial virus.Hägglund S, Hu K, Blodörn K, Makabi-Panzu B, Gaillard AL, Ellencrona K, Chevret D, Hellman L, Bengtsson KL, Riffault S, Taylor G, Valarcher JF, Eléouët JF.Clin Vaccine Immunol. 2014 Jul;21(7):997-1004. doi: 10.1128/CVI.00162-14. Epub 2014 May 14.PMID: 24828093 Free PMC article.

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation.Tanner SJ, Ariza A, Richard CA, Kyle HF, Dods RL, Blondot ML, Wu W, Trincão J, Trinh CH, Hiscox JA, Carroll MW, Silman NJ, Eléouët JF, Edwards TA, Barr JN.Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1580-5. doi: 10.1073/pnas.1317262111. Epub 2014 Jan 13.PMID: 24434552 Free PMC article.

A novel subnucleocapsid nanoplatform for mucosal vaccination against influenza virus that targets the ectodomain of matrix protein 2.Hervé PL, Raliou M, Bourdieu C, Dubuquoy C, Petit-Camurdan A, Bertho N, Eléouët JF, Chevalier C, Riffault S.J Virol. 2014 Jan;88(1):325-38. doi: 10.1128/JVI.01141-13. Epub 2013 Oct 23.PMID: 24155388 Free PMC article.


The respiratory syncytial virus nucleoprotein-RNA complex forms a left-handed helical nucleocapsid.Bakker SE, Duquerroy S, Galloux M, Loney C, Conner E, Eléouët JF, Rey FA, Bhella D.J Gen Virol. 2013 Aug;94(Pt 8):1734-1738. doi: 10.1099/vir.0.053025-0. Epub 2013 May 15.PMID: 23677789 Free PMC article.

Epidemiology, molecular virology and diagnostics of Schmallenberg virus, an emerging orthobunyavirus in Europe.Doceul V, Lara E, Sailleau C, Belbis G, Richardson J, Bréard E, Viarouge C, Dominguez M, Hendrikx P, Calavas D, Desprat A, Languille J, Comtet L, Pourquier P, Eléouët JF, Delmas B, Marianneau P, Vitour D, Zientara S.Vet Res. 2013 May 15;44(1):31. doi: 10.1186/1297-9716-44-31.PMID: 23675914 Free PMC article. Review.


Transcription et réplication des Mononegavirales : une machine moléculaire originale.Blocquel D, Bourhis JM, Éléouët JF, Gerlier D, Habchi J, Jamin M, Longhi S, Yabukarski F.Virologie (Montrouge). 2012 Aug 1;16(4):225-257. doi: 10.1684/vir.2012.0458.PMID: 33065883 English.

Structure and functional analysis of the RNA- and viral phosphoprotein-binding domain of respiratory syncytial virus M2-1 protein.Blondot ML, Dubosclard V, Fix J, Lassoued S, Aumont-Nicaise M, Bontems F, Eléouët JF, Sizun C.PLoS Pathog. 2012;8(5):e1002734. doi: 10.1371/journal.ppat.1002734. Epub 2012 May 31.PMID: 22675274 Free PMC article.

Nucleoprotein nanostructures combined with adjuvants adapted to the neonatal immune context: a candidate mucosal RSV vaccine.Remot A, Roux X, Dubuquoy C, Fix J, Bouet S, Moudjou M, Eléouët JF, Riffault S, Petit-Camurdan A.PLoS One. 2012;7(5):e37722. doi: 10.1371/journal.pone.0037722. Epub 2012 May 24.PMID: 22655066 Free PMC article.

Characterization of a viral phosphoprotein binding site on the surface of the respiratory syncytial nucleoprotein.Galloux M, Tarus B, Blazevic I, Fix J, Duquerroy S, Eléouët JF.J Virol. 2012 Aug;86(16):8375-87. doi: 10.1128/JVI.00058-12. Epub 2012 May 23.PMID: 22623798 Free PMC article.


The insertion of fluorescent proteins in a variable region of respiratory syncytial virus L polymerase results in fluorescent and functional enzymes but with reduced activities.Fix J, Galloux M, Blondot ML, Eléouët JF.Open Virol J. 2011;5:103-8. doi: 10.2174/1874357901105010103. Epub 2011 Sep 6.PMID: 21966341 Free PMC article.

1H, 13C, and 15N resonance assignment of the central domain of hRSV transcription antitermination factor M2-1.Dubosclard V, Blondot ML, Eléouët JF, Bontems F, Sizun C.Biomol NMR Assign. 2011 Oct;5(2):237-9. doi: 10.1007/s12104-011-9308-3. Epub 2011 Apr 27.PMID: 21523439


A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus.Riffault S, Meyer G, Deplanche M, Dubuquoy C, Durand G, Soulestin M, Castagné N, Bernard J, Bernardet P, Dubosclard V, Bernex F, Petit-Camurdan A, Deville S, Schwartz-Cornil I, Eléouët JF.Vaccine. 2010 May 7;28(21):3722-34. doi: 10.1016/j.vaccine.2010.03.008. Epub 2010 Mar 20.PMID: 20307593 Free PMC article.


Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus.Tawar RG, Duquerroy S, Vonrhein C, Varela PF, Damier-Piolle L, Castagné N, MacLellan K, Bedouelle H, Bricogne G, Bhella D, Eléouët JF, Rey FA.Science. 2009 Nov 27;326(5957):1279-83. doi: 10.1126/science.1177634.PMID: 19965480 Free article.

The respiratory syncytial virus M2-1 protein forms tetramers and interacts with RNA and P in a competitive manner.Tran TL, Castagné N, Dubosclard V, Noinville S, Koch E, Moudjou M, Henry C, Bernard J, Yeo RP, Eléouët JF.J Virol. 2009 Jul;83(13):6363-74. doi: 10.1128/JVI.00335-09. Epub 2009 Apr 22.PMID: 19386701 Free PMC article.


Sub-nucleocapsid nanoparticles: a nasal vaccine against respiratory syncytial virus.Roux X, Dubuquoy C, Durand G, Tran-Tolla TL, Castagné N, Bernard J, Petit-Camurdan A, Eléouët JF, Riffault S.PLoS One. 2008 Mar 12;3(3):e1766. doi: 10.1371/journal.pone.0001766.PMID: 18335041 Free PMC article.


The nine C-terminal amino acids of the respiratory syncytial virus protein P are necessary and sufficient for binding to ribonucleoprotein complexes in which six ribonucleotides are contacted per N protein protomer.Tran TL, Castagné N, Bhella D, Varela PF, Bernard J, Chilmonczyk S, Berkenkamp S, Benhamo V, Grznarova K, Grosclaude J, Nespoulos C, Rey FA, Eléouët JF.J Gen Virol. 2007 Jan;88(Pt 1):196-206. doi: 10.1099/vir.0.82282-0.PMID: 17170452


Replication of bovine respiratory syncytial virus in murine cells depends on type I interferon-receptor functionality.Riffault S, Dubuquoy C, Castagné N, Baranowski E, Charley B, Eléouët JF.J Gen Virol. 2006 Aug;87(Pt 8):2145-2148. doi: 10.1099/vir.0.82091-0.PMID: 16847109


Biochemical characterization of the respiratory syncytial virus P-P and P-N protein complexes and localization of the P protein oligomerization domain.Castagné N, Barbier A, Bernard J, Rezaei H, Huet JC, Henry C, Costa BD, Eléouët JF.J Gen Virol. 2004 Jun;85(Pt 6):1643-1653. doi: 10.1099/vir.0.79830-0.PMID: 15166449