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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Unité de Virologie et Immunologie Moléculaires


Tetramerization of Phosphoprotein is Essential for Respiratory Syncytial Virus Budding while its N Terminal Region Mediates Direct Interactions with the Matrix Protein. Bajorek M, Galloux M, Richard CA, Szekely O, Rosenzweig R, Sizun C, Eleouet JF. J Virol. 2021 Jan 6:JVI.02217-20. doi: 10.1128/JVI.02217-20. Epub ahead of print. PMID: 33408180.

Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection. Pålsson SA, Dondalska A, Bergenstråhle J, Rolfes C, Björk A, Sedano L, Power UF, Rameix-Welti MA, Lundeberg J, Wahren-Herlenius M, Mastrangelo P, Eleouet JF, Le Goffic R, Galloux M, Spetz AL. Front Immunol. 2020 Dec 8;11:580547. doi: 10.3389/fimmu.2020.580547. PMID: 33363532; PMCID: PMC7752805.

Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro. Galloux M, Risso-Ballester J, Richard CA, Fix J, Rameix-Welti MA, Eléouët JF. mBio. 2020 Sep 22;11(5):e01202-20. doi: 10.1128/mBio.01202-20. PMID: 32963000; PMCID: PMC7512546.

Regulatory B Lymphocytes Colonize the Respiratory Tract of Neonatal Mice and Modulate Immune Responses of Alveolar Macrophages to RSV Infection in IL-10-Dependant Manner. Laubreton D, Drajac C, Eléouët JF, Rameix-Welti MA, Lo-Man R, Riffault S, Descamps D. Viruses. 2020 Jul 29;12(8):822. doi: 10.3390/v12080822. PMID: 32751234; PMCID: PMC7472339.

Targeting the Respiratory Syncytial Virus N0-P Complex with Constrained α-Helical Peptides in Cells and Mice. Galloux M, Gsponer N, Gaillard V, Fenner B, Larcher T, Vilotte M, Rivière J, Richard CA, Eléouët JF, Le Goffic R, Mettier J, Nyanguile O. Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00717-20. doi: 10.1128/AAC.00717-20. PMID: 32660994; PMCID: PMC7508628.

Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like Restrict Replication of Respiratory Syncytial Virus. Busse DC, Habgood-Coote D, Clare S, Brandt C, Bassano I, Kaforou M, Herberg J, Levin M, Eléouët JF, Kellam P, Tregoning JS. J Virol. 2020 Aug 31;94(18):e00297-20. doi: 10.1128/JVI.00297-20. PMID: 32611756; PMCID: PMC7459546.

Réplication du virus respiratoire syncytial : aspects moléculaires ; un guide pour le développement d’antiviraux [Molecular mechanisms of respiratory syncytial virus replication: a guide for the development of antivirals]. Eléouët JF. Virologie (Montrouge). 2020 Apr 1;24(2):99-112. French. doi: 10.1684/vir.2020.0834. PMID: 32540831.

A Single Shot Pre-fusion-Stabilized Bovine RSV F Vaccine is Safe and Effective in Newborn Calves with Maternally Derived Antibodies. Riffault S, Hägglund S, Guzman E, Näslund K, Jouneau L, Dubuquoy C, Pietralunga V, Laubreton D, Boulesteix O, Gauthier D, Remot A, Boukaridi A, Falk A, Shevchenko G, Lind SB, Vargmar K, Zhang B, Kwong PD, Rodriguez MJ, Duran MG, Schwartz-Cornil I, Eléouët JF, Taylor G, Valarcher JF. Vaccines (Basel). 2020 May 18;8(2):231. doi: 10.3390/vaccines8020231. PMID: 32443437; PMCID: PMC7349975.

De novo protein design enables the precise induction of RSV-neutralizing antibodies. Sesterhenn F, Yang C, Bonet J, Cramer JT, Wen X, Wang Y, Chiang CI, Abriata LA, Kucharska I, Castoro G, Vollers SS, Galloux M, Dheilly E, Rosset S, Corthésy P, Georgeon S, Villard M, Richard CA, Descamps D, Delgado T, Oricchio E, Rameix-Welti MA, Más V, Ervin S, Eléouët JF, Riffault S, Bates JT, Julien JP, Li Y, Jardetzky T, Krey T, Correia BE. Science. 2020 May 15;368(6492):eaay5051. doi: 10.1126/science.aay5051. PMID: 32409444; PMCID: PMC7391827.

Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry. Blockus S, Sake SM, Wetzke M, Grethe C, Graalmann T, Pils M, Le Goffic R, Galloux M, Prochnow H, Rox K, Hüttel S, Rupcic Z, Wiegmann B, Dijkman R, Rameix-Welti MA, Eléouët JF, Duprex WP, Thiel V, Hansen G, Brönstrup M, Haid S, Pietschmann T. Antiviral Res. 2020 May;177:104774. doi: 10.1016/j.antiviral.2020.104774. Epub 2020 Mar 18. PMID: 32197980.

Respiratory syncytial virus tropism for olfactory sensory neurons in mice. Bryche B, Frétaud M, Saint-Albin Deliot A, Galloux M, Sedano L, Langevin C, Descamps D, Rameix-Welti MA, Eléouët JF, Le Goffic R, Meunier N. J Neurochem. 2019 Dec 7:e14936. doi: 10.1111/jnc.14936.

A small fragmented P protein of respiratory syncytial virus inhibits virus infection by targeting P protein. Hara K, Yaita K, Khamrin P, Kumthip K, Kashiwagi T, Eléouët JF, Rameix-Welti MA, Watanabe H. J Gen Virol. 2019 Nov 8. doi: 10.1099/jgv.0.001350.

The Interactome analysis of the Respiratory Syncytial Virus protein M2-1 suggests a new role in viral mRNA metabolism post-transcription. Bouillier C, Cosentino G, Léger T, Rincheval V, Richard CA, Desquesnes A, Sitterlin D, Blouquit-Laye S, Eléouët JF, Gault E, Rameix-Welti MA. Sci Rep. 2019 Oct 24;9(1):15258. doi: 10.1038/s41598-019-51746-0.

Structure of the Respiratory Syncytial Virus Polymerase Complex. Gilman MSA, Liu C, Fung A, Behera I, Jordan P, Rigaux P, Ysebaert N, Tcherniuk S, Sourimant J, Eléouët JF, Sutto-Ortiz P, Decroly E, Roymans D, Jin Z, McLellan JS. Cell. 2019 Sep 19;179(1):193-204.e14. doi: 10.1016/j.cell.2019.08.014.

High-throughput screening of active compounds against human respiratory syncytial virus. Fu YH, Xu ZX, Jiang N, Zheng YP, Rameix-Welti MA, Jiao YY, Peng XL, Wang Y, Eleouet JF, Cen S, He JS. Virology. 2019 Jul 3;535:171-178. doi: 10.1016/j.virol.2019.07.002.

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses. Bouillier C, Rincheval V, Sitterlin D, Blouquit-Laye S, Desquesnes A, Eléouët JF, Gault E, Rameix-Welti MA. J Vis Exp. 2019 Apr 4;(146). doi: 10.3791/59218.

Evaluation of the Antiviral Activity of Sephin1 Treatment and Its Consequences on eIF2α Phosphorylation in Response to Viral Infections. Fusade-Boyer M, Dupré G, Bessière P, Khiar S, Quentin-Froignant C, Beck C, Lecollinet S, Rameix-Welti MA, Eléouët JF, Tangy F, Lajoie B, Bertagnoli S, Vidalain PO, Gallardo F, Volmer R. Front Immunol. 2019 Feb 12;10:134. doi: 10.3389/fimmu.2019.00134.

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen. Sesterhenn F, Galloux M, Vollers SS, Csepregi L, Yang C, Descamps D, Bonet J, Friedensohn S, Gainza P, Corthésy P, Chen M, Rosset S, Rameix-Welti MA, Éléouët JF, Reddy ST, Graham BS, Riffault S, Correia BE. PLoS Biol. 2019 Feb 21;17(2):e3000164. doi: 10.1371/journal.pbio.3000164. eCollection 2019 Feb.

Biochemical characterization of the respiratory syncytial virus N -P complex in solution. Esneau C, Raynal B, Roblin P, Brûlé S, Richard CA, Fix J, Eléouët JF, Galloux M. J Biol Chem. 2019 Mar 8;294(10):3647-3660. doi: 10.1074/jbc.RA118.006453.

Does Intrinsic Disorder in Proteins Favor Their Interaction with Lipids? Deryusheva E, Nemashkalova E, Galloux M, Richard CA, Eléouët JF, Kovacs D, Van Belle K, Tompa P, Uversky V, Permyakov S. Proteomics. 2019 Mar;19(6):e1800098. doi: 10.1002/pmic.201800098.

First demonstration of the circulation of a pneumovirus in French pigs by detection of anti-swine orthopneumovirus nucleoprotein antibodies. Richard CA, Hervet C, Ménard D, Gutsche I, Normand V, Renois F, Meurens F, Eléouët JF. Vet Res. 2018 Dec 5;49(1):118. doi: 10.1186/s13567-018-0615-x.

The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex. Selvaraj M, Yegambaram K, Todd EJAA, Richard CA, Dods RL, Pangratiou GM, Trinh CH, Moul SL, Murphy JC, Mankouri J, Éléouët JF, Barr JN, Edwards TA. MBio. 2018 Nov 13;9(6). pii: e01554-18. doi: 10.1128/mBio.01554-18.

RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription. Richard CA, Rincheval V, Lassoued S, Fix J, Cardone C, Esneau C, Nekhai S, Galloux M, Rameix-Welti MA, Sizun C, Eléouët JF. PLoS Pathog. 2018 Feb 28;14(3):e1006920. doi: 10.1371/journal.ppat.1006920. eCollection 2018 Mar.

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism. Cagno V, Andreozzi P, D'Alicarnasso M, Jacob Silva P, Mueller M, Galloux M, Le Goffic R, Jones ST, Vallino M, Hodek J, Weber J, Sen S, Janeček ER, Bekdemir A, Sanavio B, Martinelli C, Donalisio M, Rameix Welti MA, Eleouet JF, Han Y, Kaiser L, Vukovic L, Tapparel C, Král P, Krol S, Lembo D, Stellacci F. Nat Mater. 2018 Feb;17(2):195-203. doi: 10.1038/nmat5053.

Modular cell-based platform for high throughput identification of compounds that inhibit a viral interferon antagonist of choice. Vasou A, Paulus C, Narloch J, Gage ZO, Rameix-Welti MA, Eléouët JF, Nevels M, Randall RE, Adamson CS. Antiviral Res. 2018 Feb;150:79-92. doi: 10.1016/j.antiviral.2017.10.012.

Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus. Rincheval V, Lelek M, Gault E, Bouillier C, Sitterlin D, Blouquit-Laye S, Galloux M, Zimmer C, Eleouet JF, Rameix-Welti MA. Nat Commun. 2017 Sep 15;8(1):563. doi: 10.1038/s41467-017-00655-9.

Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity. Zhivaki D, Lemoine S, Lim A, Morva A, Vidalain PO, Schandene L, Casartelli N, Rameix-Welti MA, Hervé PL, Dériaud E, Beitz B, Ripaux-Lefevre M, Miatello J, Lemercier B, Lorin V, Descamps D, Fix J, Eléouët JF, Riffault S, Schwartz O, Porcheray F, Mascart F, Mouquet H, Zhang X, Tissières P, Lo-Man R. Immunity. 2017 Feb 21;46(2):301-314. doi: 10.1016/j.immuni.2017.01.010.

A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading. Gaillard V, Galloux M, Garcin D, Eléouët JF, Le Goffic R, Larcher T, Rameix-Welti MA, Boukadiri A, Héritier J, Segura JM, Baechler E, Arrell M, Mottet-Osman G, Nyanguile O. Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02241-16. doi: 10.1128/AAC.02241-16.

New Insights into Structural Disorder in Human Respiratory Syncytial Virus Phosphoprotein and Implications for Binding of Protein Partners. Pereira N, Cardone C, Lassoued S, Galloux M, Fix J, Assrir N, Lescop E, Bontems F, Eléouët JF, Sizun C. J Biol Chem. 2016 Dec 28. pii: jbc.M116.765958. doi: 10.1074/jbc.M116.765958.

Non-invasive epicutaneous vaccine against Respiratory Syncytial Virus: Preclinical proof of concept. Hervé PL, Descamps D, Deloizy C, Dhelft V, Laubreton D, Bouguyon E, Boukadiri A, Dubuquoy C, Larcher T, Benhamou PH, Eléouët JF, Bertho N, Mondoulet L, Riffault S. J Control Release. 2016 Dec 10;243:146-159. doi: 10.1016/j.jconrel.2016.10.003.

RSV N-nanorings fused to palivizumab-targeted neutralizing epitope as a nanoparticle RSV vaccine. Hervé PL, Deloizy C, Descamps D, Rameix-Welti MA, Fix J, McLellan JS, Eléouët JF, Riffault S. Nanomedicine. 2016 Aug 20. pii: S1549-9634(16)30114-9. doi: 10.1016/j.nano.2016.08.006.

Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication. Bailly B, Richard CA, Sharma G, Wang L, Johansen L, Cao J, Pendharkar V, Sharma DC, Galloux M, Wang Y, Cui R, Zou G, Guillon P, von Itzstein M, Eléouët JF, Altmeyer R. Sci Rep. 2016 May 19;6:25806. doi: 10.1038/srep25806.

A druggable pocket at the nucleocapsid/phosphoprotein interaction site of the human respiratory syncytial virus. Ouizougun-Oubari M, Pereira N, Tarus B, Galloux M, Lassoued S, Fix J, Tortorici MA, Hoos S, Baron B, England P, Desmaële D, Couvreur P, Bontems F, Rey FA, Eléouët JF, Sizun C, Slama-Schwok A, Duquerroy S. J Virol. 2015 Aug 5. pii: JVI.01612-15

A bovine respiratory syncytial virus model with high clinical expression in calves with specific passive immunity. Blodörn K, Hägglund S, Gavier-Widen D, Eléouët JF, Riffault S, Pringle J, Taylor G, Valarcher JF. BMC Vet Res. 2015 Mar 25;11:76. doi: 10.1186/s12917-015-0389-6.

Fine mapping and characterization of the L-polymerase-binding domain of the respiratory syncytial virus phosphoprotein. Sourimant J, Rameix-Welti MA, Gaillard AL, Chevret D, Galloux M, Gault E, Eléouët JF. J Virol. 2015 Apr;89(8):4421-33. doi: 10.1128/JVI.03619-14. Epub 2015 Feb 4. PMID: 25653447

Identification and characterization of the binding site of the respiratory syncytial virus phosphoprotein to RNA-free nucleoprotein. Galloux M, Gabiane G, Sourimant J, Richard CA, England P, Moudjou M, Aumont-Nicaise M, Fix J, Rameix-Welti MA, Eléouët JF. J Virol. 2015 Apr;89(7):3484-96. doi: 10.1128/JVI.03666-14. Epub 2015 Jan 7. PMID: 25568210

Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important co-factors that promote L protein stability and RNA synthesis. Munday DC, Wu W, Smith N, Fix J, Noton SL, Galloux M, Touzelet O, Armstrong SD, Dawson JM, Aljabr W, Easton AJ, Rameix-Welti MA, de Oliveira AP, Simabuco F, Ventura AM, Hughes DJ, Barr JN, Fearns R, Digard P, Eléouët JF, Hiscox JA. J Virol. 2014 Oct 29.

Visualizing the replication of respiratory syncytial virus in cells and in living mice. Rameix-Welti MA, Le Goffic R, Hervé PL, Sourimant J, Rémot A, Riffault S, Yu Q, Galloux M, Gault E, Eléouët JF. Nat Commun. 2014 Oct 3;5:5104

Vaccine safety and efficacy evaluation of a recombinant bovine respiratory syncytial virus (BRSV) with deletion of the SH gene and subunit vaccines based on recombinant human RSV proteins: N-nanorings, P and M2-1, in calves with maternal antibodies. Blodörn K, Hägglund S, Fix J, Dubuquoy C, Makabi-Panzu B, Thom M, Karlsson P, Roque JL, Karlstam E, Pringle J, Eléouët JF, Riffault S, Taylor G, Valarcher JF. PLoS One. 2014 Jun 19;9(6):e100392

Characterization of an experimental vaccine for bovine respiratory syncytial virus. Hägglund S, Hu K, Blodörn K, Makabi-Panzu B, Gaillard AL, Ellencrona K, Chevret D, Hellman L, Bengtsson KL, Riffault S, Taylor G, Valarcher JF, Eléouët JF. Clin Vaccine Immunol. 2014 Jul;21(7):997-1004

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. Tanner SJ, Ariza A, Richard CA, Kyle HF, Dods RL, Blondot ML, Wu W, Trincão J, Trinh CH, Hiscox JA, Carroll MW, Silman NJ, Eléouët JF, Edwards TA, Barr JN. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1580-5.

A novel subnucleocapsid nanoplatform for mucosal vaccination against influenza virus that targets the ectodomain of matrix protein 2. Hervé PL, Raliou M, Bourdieu C, Dubuquoy C, Petit-Camurdan A, Bertho N, Eléouët JF, Chevalier C, Riffault S. J Virol. 2014 Jan;88(1):325-38.

The respiratory syncytial virus nucleoprotein-RNA complex forms a left-handed helical nucleocapsid. Bakker SE, Duquerroy S, Galloux M, Loney C, Conner E, Eléouët JF, Rey FA, Bhella D. J Gen Virol. 2013 Aug;94(Pt 8):1734-8.

Structure and functional analysis of the RNA- and viral phosphoprotein-binding domain of respiratory syncytial virus M2-1 protein. Blondot ML, Dubosclard V, Fix J, Lassoued S, Aumont-Nicaise M, Bontems F, Eléouët JF, Sizun C. PLoS Pathog. 2012;8(5):e1002734

Characterization of a viral phosphoprotein binding site on the surface of the respiratory syncytial nucleoprotein. Galloux M, Tarus B, Blazevic I, Fix J, Duquerroy S, Eléouët JF. J Virol. 2012 Aug;86(16):8375-87

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