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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Unité de Virologie et Immunologie Moléculaires

Micheline Lagranderie and Gilles Marchal (Institut Pasteur, Paris)

13 January 2011 - INRA Jouy-en-Josas

Mycobacterium tuberculosis
"Mycobacterium bovis Bacillus Calmette-Guérin killed by extended freeze-drying protects against asthma, colitis and atherosclerosis"

Gilles Marchal (Professor at Institut Pasteur, Paris) and Micheline Lagranderie (engineer, Institut Pasteur, Paris)


Asthma is a highly prevalent and serious health problem. In a murine experimental model of asthma, Gilles Marchal and Micheline Lagranderie from the Institut Pasteur (Paris) studied the curative effect of BCG inactivated by freeze drying (EFD).

After EFD-treatment, the parameters of asthma (airways eosinophilia and inflammation, bronchial hyperreactivity) were reduced. They further showed that EFD-BCG induced plasmacytoid dendritic cells recruitment leading to the production of IL10 regulatory T lymphocytes. EFD-BCG  administered in mice was also effective against gut inflammation and atherosclerosis.

This work illustrates the immunomodulatory effects of bacterial structures that remain to be discovered.

Recent Publications:

Mycobacterium bovis bacillus Calmette-Guérin killed by extended freeze-drying targets plasmacytoid dendritic cells to regulate lung inflammation.
Lagranderie M, Abolhassani M, Vanoirbeek JA, Lima C, Balazuc AM, Vargaftig BB, Marchal G.
J Immunol. 2010 Jan 15;184(2):1062-70.

Mycobacterium bovis BCG killed by extended freeze-drying reduces airway hyperresponsiveness in 2 animal models.
Lagranderie M, Abolhassani M, Vanoirbeek J, Lefort J, Nahori MA, Lapa E Silva JR, Huerre M, Vargaftig B, Marchal G.
J Allergy Clin Immunol. 2008 Feb;121(2):471-8.

Similar functional activity of dendritic cells recruited to the mesenteric lymph nodes of newborn and adult mice after the rectal delivery of Mycobacterium bovis BCG.
Abolhassani M, Lagranderie M, Caminshi I, Romain F, Balazuc AM, Wagner MC, Tanguy M, Fiette L, Sobhani I, Milon G, Marchal G.
Microbes Infect. 2006 Aug;8(9-10):2341-51.

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