Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal


Unité de Virologie et Immunologie Moléculaires

Blaise Corthésy (Immunology and Allergies Division, Hôpital orthopédique, Lausanne, Switzerland)

24 May 2012 - Institute Seminar - INRA Jouy-en-Josas

24/05/12 Blaise Corthésy (Hôpital orthopédique, Lausanne, Switzerland)
"Role of IgA in intestinal homeostasis"

On Thursday 24 May, 10.30am, Lecture Hall of J.Poly building (440), Dr Blaise Corthésy (Immunology and Allergies Division, Hôpital orthopédique, Lausanne, Switzerland), hosted by Isabelle Schwartz-Cornil, will give an Institute seminar focused on the role of IgA in intestinal homeostasis.

Mucosal host defense against pathogens is mainly controlled by a specific type of immunoglobulins, called IgA. Secretory IgAs from mucosal surfaces act by complexing pathogens (virus, bacteria, parasites) through the so-called "immune exclusion" mechanism, leading to their subsequent elimination.

Recent findings from Dr Blaise Corthésy's laboratory in Lausanne further extend the role of IgAs to intestinal mucosa homeostasis, through subtle and complex interactions with commensal flora, epithelial and dendritic cells.

This work enables a better understanding of host/microbiota interactions and of host defense mechanisms against pathogens entering through mucosa, and has a direct impact on the development of immunisation strategies.

To learn more:

Recent publications:

N-Glycans on secretory component: Mediators of the interaction between secretory IgA and gram-positive commensals sustaining intestinal homeostasis.
Mathias A, Corthésy B.
Gut Microbes. 2011 Sep 1;2(5)

Recognition of gram-positive intestinal bacteria by hybridoma- and colostrum-derived secretory immunoglobulin A is mediated by carbohydrates.
Mathias A, Corthésy B.
J Biol Chem. 2011 May 13;286(19):17239-47

Potentiation of polarized intestinal Caco-2 cell responsiveness to probiotics complexed with secretory IgA.
Mathias A, Duc M, Favre L, Benyacoub J, Blum S, Corthésy B.
J Biol Chem. 2010 Oct 29;285(44):33906-13.

Conditioned polarized Caco-2 cell monolayers allow to discriminate for the ability of gut-derived microorganisms to modulate permeability and antigen-induced basophil degranulation.
Thierry AC, Bernasconi E, Mercenier A, Corthésy B.
Clin Exp Allergy. 2009 Apr;39(4):527-36.

Email :